NF-κB Members Left Home: NF-κB-Independent Roles in Cancer
AbstractNuclear factor-κB (NF-κB) has been long considered a master regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been linked with carcinogenesis in many types of cancer. In recent years, the study of NF-κB members in NF-κB unrelated pathways provided novel attractive targets for cancer therapy, specifically linked to particular pathologic responses. Here we review specific functions of IκB kinase complexes (IKKs) and IκBs, which have distinctly tumor promoting or suppressing activities in cancer. Understanding how these proteins are regulated in a tumor-related context will provide new opportunities for drug development. View Full-Text
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Colomer, C.; Marruecos, L.; Vert, A.; Bigas, A.; Espinosa, L. NF-κB Members Left Home: NF-κB-Independent Roles in Cancer. Biomedicines 2017, 5, 26.
Colomer C, Marruecos L, Vert A, Bigas A, Espinosa L. NF-κB Members Left Home: NF-κB-Independent Roles in Cancer. Biomedicines. 2017; 5(2):26.Chicago/Turabian Style
Colomer, Carlota; Marruecos, Laura; Vert, Anna; Bigas, Anna; Espinosa, Lluis. 2017. "NF-κB Members Left Home: NF-κB-Independent Roles in Cancer." Biomedicines 5, no. 2: 26.