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Biomedicines 2017, 5(1), 5; doi:10.3390/biomedicines5010005

Targeting Autophagy for Oncolytic Immunotherapy

1,†
,
1,†
,
2,* and 1,*
1
Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, 9Lvshun Road South, Dalian 116044, China
2
Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200000, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editors: Zong Sheng Guo and David L. Bartlett
Received: 18 November 2016 / Revised: 22 December 2016 / Accepted: 4 January 2017 / Published: 11 January 2017
(This article belongs to the Special Issue Oncolytic Viruses as a Novel Form of Immunotherapy for Cancer)
View Full-Text   |   Download PDF [192 KB, uploaded 11 January 2017]   |  

Abstract

Oncolytic viruses (OVs) are capable of exerting anti-cancer effects by a variety of mechanisms, including immune-mediated tumor cell death, highlighting their potential use in immunotherapy. Several adaptation mechanisms such as autophagy contribute to OV-mediated anti-tumor properties. Autophagy regulates immunogenic signaling during cancer therapy which can be utilized to design therapeutic combinations using approaches that either induce or block autophagy to potentiate the therapeutic efficacy of OVs. In this article, we review the complicated interplay between autophagy, cancer, immunity, and OV, summarize recent progress in the contribution of OV-perturbed autophagy to oncolytic immunity, and discuss the challenges in targeting autophagy to enhance oncolytic immunotherapy. View Full-Text
Keywords: oncolytic virus (OV); autophagy; immunotherapy; cancer oncolytic virus (OV); autophagy; immunotherapy; cancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Hu, L.; Jiang, K.; Ding, C.; Meng, S. Targeting Autophagy for Oncolytic Immunotherapy. Biomedicines 2017, 5, 5.

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