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Biomedicines 2017, 5(1), 1; doi:10.3390/biomedicines5010001

Aptamer Technology: Adjunct Therapy for Malaria

Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Health Campus, Kubang Kerian, 16150 Kelantan, Malaysia
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Author to whom correspondence should be addressed.
Academic Editor: Vittorio de Franciscis
Received: 7 November 2016 / Revised: 8 December 2016 / Accepted: 16 December 2016 / Published: 4 January 2017
(This article belongs to the Special Issue Engineering Aptamers for Biomedical Applications)
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Abstract

Malaria is a life-threatening parasitic infection occurring in the endemic areas, primarily in children under the age of five, pregnant women, and patients with human immunodeficiency virus and acquired immunodeficiency syndrome (HIV)/(AIDS) as well as non-immune individuals. The cytoadherence of infected erythrocytes (IEs) to the host endothelial surface receptor is a known factor that contributes to the increased prevalence of severe malaria cases due to the accumulation of IEs, mainly in the brain and other vital organs. Therefore, further study is needed to discover a new potential anti-adhesive drug to treat severe malaria thus reducing its mortality rate. In this review, we discuss how the aptamer technology could be applied in the development of a new adjunct therapy for current malaria treatment. View Full-Text
Keywords: Plasmodium falciparum; malaria; cytoadherence; adjunct therapy; aptamer Plasmodium falciparum; malaria; cytoadherence; adjunct therapy; aptamer
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Nik Kamarudin, N.A.A.; Mohammed, N.A.; Mustaffa, K.M.F. Aptamer Technology: Adjunct Therapy for Malaria. Biomedicines 2017, 5, 1.

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