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Biomedicines 2016, 4(4), 28; doi:10.3390/biomedicines4040028

Cellular and Molecular Preconditions for Retinal Pigment Epithelium (RPE) Natural Reprogramming during Retinal Regeneration in Urodela

Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow 119334, Russia
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Academic Editor: Wenbin Deng
Received: 19 October 2016 / Revised: 26 November 2016 / Accepted: 26 November 2016 / Published: 1 December 2016
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Abstract

Many regeneration processes in animals are based on the phenomenon of cell reprogramming followed by proliferation and differentiation in a different specialization direction. An insight into what makes natural (in vivo) cell reprogramming possible can help to solve a number of biomedical problems. In particular, the first problem is to reveal the intrinsic properties of the cells that are necessary and sufficient for reprogramming; the second, to evaluate these properties and, on this basis, to reveal potential endogenous sources for cell substitution in damaged tissues; and the third, to use the acquired data for developing approaches to in vitro cell reprogramming in order to obtain a cell reserve for damaged tissue repair. Normal cells of the retinal pigment epithelium (RPE) in newts (Urodela) can change their specialization and transform into retinal neurons and ganglion cells (i.e., actualize their retinogenic potential). Therefore, they can serve as a model that provides the possibility to identify factors of the initial competence of vertebrate cells for reprogramming in vivo. This review deals mainly with the endogenous properties of native newt RPE cells themselves and, to a lesser extent, with exogenous mechanisms regulating the process of reprogramming, which are actively discussed. View Full-Text
Keywords: eye; retinal regeneration; retinal pigment epithelium; reprogramming; molecular prerequisites eye; retinal regeneration; retinal pigment epithelium; reprogramming; molecular prerequisites
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MDPI and ACS Style

Grigoryan, E.N.; Markitantova, Y.V. Cellular and Molecular Preconditions for Retinal Pigment Epithelium (RPE) Natural Reprogramming during Retinal Regeneration in Urodela. Biomedicines 2016, 4, 28.

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