Cellular and Molecular Preconditions for Retinal Pigment Epithelium (RPE) Natural Reprogramming during Retinal Regeneration in Urodela
Abstract
:1. Introduction
2. Regeneration of Neural Retina (NR) from Retinal Pigmented Epithelium (RPE) in Urodela
3. Newt Eye Development and Retention of Pedomorphic Features in the Retina
4. Differentiation of Newt RPE Cells and Conditions of Its Stabilization
5. Proliferative Activity of Adult Newt RPE Cells in the Course of In Vivo Reprogramming
5.1. Persistent Cell Proliferation in the RPE
5.2. Mechanism of Activation of Newt RPE Cell Entry into the S-Phase
6. Competence of Adult Newt RPE Cells for Differentiation into Nonretinal Cell Types
6.1. RPE Cell Conversion into Neuronal and Lentoid Phenotypes In Vitro
6.2. Transformation of Newt RPE Cells into Melanophages In Vitro
7. Specific Features of Cytoskeleton, Cell Contacts, and Extracellular Matrix Components in the Newt RPE
8. Transcription Factors and Signal Molecules Characteristic of Progenitor Cells in the Adult Newt RPE
9. Epigenetic Factors in Cell of Normal RPE and at Early Stages of Reprogramming
9.1. Chromatin Reorganization in Cells of Adult Newt RPE at the Onset of Reprogramming
9.2. Nucleostemin Expression
10. Conclusions
Acknowledgments
Conflicts of Interest
References
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Grigoryan, E.N.; Markitantova, Y.V. Cellular and Molecular Preconditions for Retinal Pigment Epithelium (RPE) Natural Reprogramming during Retinal Regeneration in Urodela. Biomedicines 2016, 4, 28. https://doi.org/10.3390/biomedicines4040028
Grigoryan EN, Markitantova YV. Cellular and Molecular Preconditions for Retinal Pigment Epithelium (RPE) Natural Reprogramming during Retinal Regeneration in Urodela. Biomedicines. 2016; 4(4):28. https://doi.org/10.3390/biomedicines4040028
Chicago/Turabian StyleGrigoryan, Eleonora N., and Yuliya V. Markitantova. 2016. "Cellular and Molecular Preconditions for Retinal Pigment Epithelium (RPE) Natural Reprogramming during Retinal Regeneration in Urodela" Biomedicines 4, no. 4: 28. https://doi.org/10.3390/biomedicines4040028