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Biomedicines 2016, 4(3), 20; doi:10.3390/biomedicines4030020

Emerging Therapeutic Potential of Nanoparticles in Pancreatic Cancer: A Systematic Review of Clinical Trials

Public Health and Tropical Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, James Cook Drive, Douglas, Townsville QLD 4811, Australia
Townsville Cancer Centre, The Townsville Hospital, Townsville QLD 4814, Australia
College of Medicine and Dentistry, James Cook University, James Cook Drive, Douglas, Townsville QLD 4811, Australia
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Shaker A. Mousa
Received: 15 June 2016 / Revised: 12 August 2016 / Accepted: 16 August 2016 / Published: 19 August 2016
(This article belongs to the Section Tumor Immunology and Immunotherapy)
View Full-Text   |   Download PDF [867 KB, uploaded 19 August 2016]   |  


Pancreatic cancer is an aggressive disease with a five year survival rate of less than 5%, which is associated with late presentation. In recent years, research into nanomedicine and the use of nanoparticles as therapeutic agents for cancers has increased. This article describes the latest developments in the use of nanoparticles, and evaluates the risks and benefits of nanoparticles as an emerging therapy for pancreatic cancer. The Preferred Reporting Items of Systematic Reviews and Meta-Analyses checklist was used. Studies were extracted by searching the Embase, MEDLINE, SCOPUS, Web of Science, and Cochrane Library databases from inception to 18 March 2016 with no language restrictions. Clinical trials involving the use of nanoparticles as a therapeutic or prognostic option in patients with pancreatic cancer were considered. Selected studies were evaluated using the Jadad score for randomised control trials and the Therapy CA Worksheet for intervention studies. Of the 210 articles found, 10 clinical trials including one randomised control trial and nine phase I/II clinical trials met the inclusion criteria and were analysed. These studies demonstrated that nanoparticles can be used in conjunction with chemotherapeutic agents increasing their efficacy whilst reducing their toxicity. Increased efficacy of treatment with nanoparticles may improve the clinical outcomes and quality of life in patients with pancreatic cancer, although the long-term side effects are yet to be defined. The study registration number is CRD42015020009. View Full-Text
Keywords: pancreatic cancer; nanoparticles; clinical trials; cancer therapy pancreatic cancer; nanoparticles; clinical trials; cancer therapy

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Au, M.; Emeto, T.I.; Power, J.; Vangaveti, V.N.; Lai, H.C. Emerging Therapeutic Potential of Nanoparticles in Pancreatic Cancer: A Systematic Review of Clinical Trials. Biomedicines 2016, 4, 20.

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