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Oncolytic Adenoviruses in Cancer Treatment
Catalan Institute of Oncology (ICO), Av. Gran Via s/n km 2,7, Hospitalet de Llobregat, Barcelona 08907, Spain
Biomedical Research Institute of Bellvitge (IDIBELL), 3a planta - Gran Via de l'Hospitalet, 199, Hospitalet de Llobregat, Barcelona 08907, Spain
Received: 15 January 2014; in revised form: 13 February 2014 / Accepted: 14 February 2014 / Published: 21 February 2014
Abstract: The therapeutic use of viruses against cancer has been revived during the last two decades. Oncolytic viruses replicate and spread inside tumors, amplifying their cytotoxicity and simultaneously reversing the tumor immune suppression. Among different viruses, recombinant adenoviruses designed to replicate selectively in tumor cells have been clinically tested by intratumoral or systemic administration. Limited efficacy has been associated to poor tumor targeting, intratumoral spread, and virocentric immune responses. A deeper understanding of these three barriers will be required to design more effective oncolytic adenoviruses that, alone or combined with chemotherapy or immunotherapy, may become tools for oncologists.
Keywords: oncolytic; adenovirus; virotherapy; cancer
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MDPI and ACS Style
Alemany, R. Oncolytic Adenoviruses in Cancer Treatment. Biomedicines 2014, 2, 36-49.
Alemany R. Oncolytic Adenoviruses in Cancer Treatment. Biomedicines. 2014; 2(1):36-49.
Alemany, Ramon. 2014. "Oncolytic Adenoviruses in Cancer Treatment." Biomedicines 2, no. 1: 36-49.