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Biomedicines 2014, 2(1), 36-49; doi:10.3390/biomedicines2010036

Oncolytic Adenoviruses in Cancer Treatment

Received: 15 January 2014 / Revised: 13 February 2014 / Accepted: 14 February 2014 / Published: 21 February 2014
(This article belongs to the Special Issue Gene Therapy Used in Cancer Treatment)
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Abstract: The therapeutic use of viruses against cancer has been revived during the last two decades. Oncolytic viruses replicate and spread inside tumors, amplifying their cytotoxicity and simultaneously reversing the tumor immune suppression. Among different viruses, recombinant adenoviruses designed to replicate selectively in tumor cells have been clinically tested by intratumoral or systemic administration. Limited efficacy has been associated to poor tumor targeting, intratumoral spread, and virocentric immune responses. A deeper understanding of these three barriers will be required to design more effective oncolytic adenoviruses that, alone or combined with chemotherapy or immunotherapy, may become tools for oncologists.
Keywords: oncolytic; adenovirus; virotherapy; cancer oncolytic; adenovirus; virotherapy; cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Alemany, R. Oncolytic Adenoviruses in Cancer Treatment. Biomedicines 2014, 2, 36-49.

AMA Style

Alemany R. Oncolytic Adenoviruses in Cancer Treatment. Biomedicines. 2014; 2(1):36-49.

Chicago/Turabian Style

Alemany, Ramon. 2014. "Oncolytic Adenoviruses in Cancer Treatment." Biomedicines 2, no. 1: 36-49.

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