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Chemosensors 2017, 5(1), 4; doi:10.3390/chemosensors5010004

Investigation of the Influence of the As-Grown ZnO Nanorods and Applied Potentials on an Electrochemical Sensor for In-Vitro Glucose Monitoring

1
Microelectronics and Photonics graduate program, University of Arkansas, Fayetteville, AR 72701, USA
2
Department of Electrical Engineering, University of Arkansas, Fayetteville, AR 72701, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Franz L. Dickert
Received: 15 August 2016 / Revised: 15 December 2016 / Accepted: 23 January 2017 / Published: 26 January 2017
(This article belongs to the Special Issue Advanced in Glucose Biosensing)
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Abstract

The influence of the as-grown zinc oxide nanorods (ZnO NRs) on the fabricated electrochemical sensor for in vitro glucose monitoring were investigated. A direct growth of ZnO NRs was performed on the Si/SiO2/Au electrode, using hydrothermal and sol-gel techniques at low temperatures. The structure, consisting of a Si/SiO2/Au/GOx/Nafion membrane, was considered as a baseline, and it was tested under several applied potential 0.1–0.8 V. The immobilized working electrode, with GOx and a nafion membrane, was characterized amperometrically using a source meter Keithely 2410, and an electrochemical impedance Gamry potentiostat. The sensor exhibited the following: a high sensitivity of ~0.468 mA/cm2 mM, a low detection limit in the order of 166.6 µM, and a fast and sharp response time of around 2 s. The highest sensitivity and the lowest limit of detection were obtained at 0.4 volt, after the growth of ZnO NRs. The highest net sensitivity was obtained after subtracting the sensitivity of the baseline, and it was in the order of 0.315 mA/cm2·mM. The device was tested with a range of glucose concentrations from 1–10 mM, showing a linear line from 3–8 mM, and the device was saturated after exceeding high concentrations of glucose. Such devices can be used for in vitro glucose monitoring, since glucose changes can be accurately detected. View Full-Text
Keywords: electrochemical sensor; glucose oxidase; amperometric; sensitivity; concentrations. electrochemical sensor; glucose oxidase; amperometric; sensitivity; concentrations.
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Marie, M.; Manasreh, O. Investigation of the Influence of the As-Grown ZnO Nanorods and Applied Potentials on an Electrochemical Sensor for In-Vitro Glucose Monitoring. Chemosensors 2017, 5, 4.

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