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Healthcare 2015, 3(2), 219-232; doi:10.3390/healthcare3020219

Vitamin D as an Immunomodulator: Risks with Deficiencies and Benefits of Supplementation

Department of Internal Medicine, University of Michigan, 3116G Taubman Center, SPC 5368, Ann Arbor, MI 48109, USA
Academic Editors: Samir Samman and Ian Darnton-Hill
Received: 15 March 2015 / Revised: 2 April 2015 / Accepted: 8 April 2015 / Published: 14 April 2015
(This article belongs to the Special Issue The Close Relationship: Health and Nutrition)
View Full-Text   |   Download PDF [699 KB, uploaded 14 April 2015]

Abstract

Vitamin D refers to a class of fat-soluble secosteroids often associated with their role in absorption and metabolism of minerals such as calcium and phosphate. In recent years, our understanding of vitamin D has expanded to include its role in modulating the immune system. Of particular focus are the effects of vitamin D deficiency and supplementation on patients suffering from disorders due to dysregulation of the immune system. In patients with multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease, deficiencies in vitamin D have been associated with an increased risk of disease activity. In this review, we will look at the current state of research in regards to the relationship between vitamin D and immune-dysregulation. We will focus on both the risks associated with vitamin D deficiency as well as the benefits of vitamin D supplementation. View Full-Text
Keywords: vitamin D; immune function; immunomodulator; inflammatory bowel diseases; multiple sclerosis; rheumatoid arthritis; Treg vitamin D; immune function; immunomodulator; inflammatory bowel diseases; multiple sclerosis; rheumatoid arthritis; Treg
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Goldsmith, J.R. Vitamin D as an Immunomodulator: Risks with Deficiencies and Benefits of Supplementation. Healthcare 2015, 3, 219-232.

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