Proteomes 2017, 5(4), 30; doi:10.3390/proteomes5040030
A Systematic Review and Meta-Analysis of Proteomics Literature on the Response of Human Skeletal Muscle to Obesity/Type 2 Diabetes Mellitus (T2DM) Versus Exercise Training
1
Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK
2
Bureau of Non-Communicable Diseases, Department of Diseases Control, Ministry of Public Health, Nonthaburi 11000, Thailand
3
Department of Applied Mathematics, Liverpool John Moores University, Liverpool L3 3AF, UK
*
Author to whom correspondence should be addressed.
Received: 29 September 2017 / Revised: 2 November 2017 / Accepted: 6 November 2017 / Published: 11 November 2017
Abstract
We performed a systematic review and meta-analysis of proteomics literature that reports human skeletal muscle responses in the context of either pathological decline associated with obesity/T2DM and physiological adaptations to exercise training. Literature was collected from PubMed and DOAJ databases following PRISMA guidelines using the search terms ‘proteom*’, and ‘skeletal muscle’ combined with either ‘obesity, insulin resistance, diabetes, impaired glucose tolerance’ or ‘exercise, training’. Eleven studies were included in the systematic review, and meta-analysis was performed on a sub-set (four studies) of the reviewed literature that reported the necessary primary data. The majority of proteins (n = 73) more abundant in the muscle of obese/T2DM individuals were unique to this group and not reported to be responsive to exercise training. The main response of skeletal muscle to exercise training was a greater abundance of proteins of the mitochondrial electron transport chain, tricarboxylic acid cycle and mitochondrial respiratory chain complex I assembly. In total, five proteins were less abundant in muscle of obese/T2DM individuals and were also reported to be more abundant in the muscle of endurance-trained individuals, suggesting one of the major mechanisms of exercise-induced protection against the deleterious effects of obesity/T2DM occurs at complex I of the electron transport chain. View Full-TextKeywords:
type 2 diabetes; obese; insulin resistance; high intensity exercise; protein abundance; mass spectrometry; systematic review (SR); meta-analysis (MA); Preferred Reporting items for Systematic Review and Meta-analyses (PRISMA)
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Srisawat, K.; Shepherd, S.O.; Lisboa, P.J.; Burniston, J.G. A Systematic Review and Meta-Analysis of Proteomics Literature on the Response of Human Skeletal Muscle to Obesity/Type 2 Diabetes Mellitus (T2DM) Versus Exercise Training. Proteomes 2017, 5, 30.
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