Next Article in Journal
Quantification of Cardiovascular Disease Biomarkers in Human Platelets by Targeted Mass Spectrometry
Previous Article in Journal
Proteomic Investigations of Proteases Involved in Cotyledon Senescence: A Model to Explore the Genotypic Variability of Proteolysis Machinery Associated with Nitrogen Remobilization Efficiency during the Leaf Senescence of Oilseed Rape
Article Menu

Export Article

Open AccessReview
Proteomes 2017, 5(4), 30; doi:10.3390/proteomes5040030

A Systematic Review and Meta-Analysis of Proteomics Literature on the Response of Human Skeletal Muscle to Obesity/Type 2 Diabetes Mellitus (T2DM) Versus Exercise Training

1
Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK
2
Bureau of Non-Communicable Diseases, Department of Diseases Control, Ministry of Public Health, Nonthaburi 11000, Thailand
3
Department of Applied Mathematics, Liverpool John Moores University, Liverpool L3 3AF, UK
*
Author to whom correspondence should be addressed.
Received: 29 September 2017 / Revised: 2 November 2017 / Accepted: 6 November 2017 / Published: 11 November 2017
View Full-Text   |   Download PDF [2006 KB, uploaded 11 November 2017]   |  

Abstract

We performed a systematic review and meta-analysis of proteomics literature that reports human skeletal muscle responses in the context of either pathological decline associated with obesity/T2DM and physiological adaptations to exercise training. Literature was collected from PubMed and DOAJ databases following PRISMA guidelines using the search terms ‘proteom*’, and ‘skeletal muscle’ combined with either ‘obesity, insulin resistance, diabetes, impaired glucose tolerance’ or ‘exercise, training’. Eleven studies were included in the systematic review, and meta-analysis was performed on a sub-set (four studies) of the reviewed literature that reported the necessary primary data. The majority of proteins (n = 73) more abundant in the muscle of obese/T2DM individuals were unique to this group and not reported to be responsive to exercise training. The main response of skeletal muscle to exercise training was a greater abundance of proteins of the mitochondrial electron transport chain, tricarboxylic acid cycle and mitochondrial respiratory chain complex I assembly. In total, five proteins were less abundant in muscle of obese/T2DM individuals and were also reported to be more abundant in the muscle of endurance-trained individuals, suggesting one of the major mechanisms of exercise-induced protection against the deleterious effects of obesity/T2DM occurs at complex I of the electron transport chain. View Full-Text
Keywords: type 2 diabetes; obese; insulin resistance; high intensity exercise; protein abundance; mass spectrometry; systematic review (SR); meta-analysis (MA); Preferred Reporting items for Systematic Review and Meta-analyses (PRISMA) type 2 diabetes; obese; insulin resistance; high intensity exercise; protein abundance; mass spectrometry; systematic review (SR); meta-analysis (MA); Preferred Reporting items for Systematic Review and Meta-analyses (PRISMA)
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Share & Cite This Article

MDPI and ACS Style

Srisawat, K.; Shepherd, S.O.; Lisboa, P.J.; Burniston, J.G. A Systematic Review and Meta-Analysis of Proteomics Literature on the Response of Human Skeletal Muscle to Obesity/Type 2 Diabetes Mellitus (T2DM) Versus Exercise Training. Proteomes 2017, 5, 30.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Proteomes EISSN 2227-7382 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top