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Proteomes 2016, 4(4), 29; doi:10.3390/proteomes4040029

Personalized Proteomics: The Future of Precision Medicine

Department of Biological Sciences, University of Texas at El Paso, El Paso, TX 79968, USA
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Author to whom correspondence should be addressed.
Academic Editors: Edwin Lasonder and Jacek R. Wisniewski
Received: 11 July 2016 / Revised: 9 September 2016 / Accepted: 23 September 2016 / Published: 1 October 2016
(This article belongs to the Special Issue Clinical Proteomics)
View Full-Text   |   Download PDF [710 KB, uploaded 1 October 2016]   |  

Abstract

Medical diagnostics and treatment has advanced from a one size fits all science to treatment of the patient as a unique individual. Currently, this is limited solely to genetic analysis. However, epigenetic, transcriptional, proteomic, posttranslational modifications, metabolic, and environmental factors influence a patient’s response to disease and treatment. As more analytical and diagnostic techniques are incorporated into medical practice, the personalized medicine initiative transitions to precision medicine giving a holistic view of the patient’s condition. The high accuracy and sensitivity of mass spectrometric analysis of proteomes is well suited for the incorporation of proteomics into precision medicine. This review begins with an overview of the advance to precision medicine and the current state of the art in technology and instrumentation for mass spectrometry analysis. Thereafter, it focuses on the benefits and potential uses for personalized proteomic analysis in the diagnostic and treatment of individual patients. In conclusion, it calls for a synthesis between basic science and clinical researchers with practicing clinicians to design proteomic studies to generate meaningful and applicable translational medicine. As clinical proteomics is just beginning to come out of its infancy, this overview is provided for the new initiate. View Full-Text
Keywords: proteomics; personalized medicine; precision medicine; mass spectrometry; clinical proteomics; biomarker; diagnostic; pharmacokinetics; therapeutic monitoring proteomics; personalized medicine; precision medicine; mass spectrometry; clinical proteomics; biomarker; diagnostic; pharmacokinetics; therapeutic monitoring
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Duarte, T.T.; Spencer, C.T. Personalized Proteomics: The Future of Precision Medicine. Proteomes 2016, 4, 29.

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