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Pharmacy 2018, 6(3), 84;

Validation and Feasibility of the Medication Acceptability Questionnaire to Investigate Tablet and Liquid Alendronic Acid with Older Hospital Patients

School of Pharmacy, University of East Anglia, Norwich, Norfolk NR4 7TJ, UK
Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK
Norfolk and Norwich University Hospital NHS Foundation Trust, Norwich, Norfolk NR4 7UY, UK
Author to whom correspondence should be addressed.
Received: 17 May 2018 / Revised: 13 July 2018 / Accepted: 9 August 2018 / Published: 11 August 2018
(This article belongs to the Special Issue Medication Adherence)
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The effects of formulation characteristics on acceptability are poorly understood. This study evaluated the validity and feasibility of using the Medication Acceptability Questionnaire (MAQ) to investigate factors influencing acceptability of tablet compared with liquid alendronic acid. Written consent was obtained from eligible patients on Older People’s Medicine wards. MAQ face and content validity were evaluated through cognitive interviews while internal consistency and criterion validity were investigated by calculating Cronbach’s alpha and correlation of MAQ items with visual analogue scale (VAS) responses. MAQ data were obtained from 33 and 25 participants for tablet and liquid formulations respectively. Cognitive interviews indicated MAQ face and content validity. The domains of appearance, efficacy, and tolerability demonstrated adequate internal consistency and suitable refinements were identified for the domains of convenience and taste with Cronbach’s alpha <0.7. Significant positive correlations were identified between all MAQ domains and VAS. The liquid trended towards performing better for taste, appearance and tolerability and the tablet for convenience and efficacy. It is feasible to capture patient acceptability of a medication by questionnaire. Interpatient variation in acceptability for two formulations indicates that medication characteristics should be considered during prescribing and medication reviews to match patient preference with the appropriate formulation. View Full-Text
Keywords: medication adherence; bisphosphonate; preference; side effect; alendronate medication adherence; bisphosphonate; preference; side effect; alendronate

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Scott, S.; Clark, A.; May, H.; Bhattacharya, D. Validation and Feasibility of the Medication Acceptability Questionnaire to Investigate Tablet and Liquid Alendronic Acid with Older Hospital Patients. Pharmacy 2018, 6, 84.

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