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Plants 2018, 7(1), 18; https://doi.org/10.3390/plants7010018

Polar Constituents of Salvia willeana (Holmboe) Hedge, Growing Wild in Cyprus

Department of Pharmacognosy & Chemistry of Natural Products, School of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 157 71 Athens, Greece
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Received: 29 January 2018 / Revised: 27 February 2018 / Accepted: 1 March 2018 / Published: 6 March 2018
(This article belongs to the Special Issue Lamiaceae Species: Biology, Ecology and Practical Uses)
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Abstract

Twenty compounds were isolated from the aerial parts of Salvia willeana (Holmboe) Hedge, growing wild in Cyprus. These compounds comprise one new and one known acetophenone, one megastigmane glucoside, five phenolic derivatives, two caffeic acid oligomers, three flavonoids, two lignans, two triterpene acids, one monoterpene glucoside, and two fatty acids. The structures of the isolated compounds were established by means of NMR [(Rotating-frame OverhauserEffect SpectroscopY) (1H-1H-COSY (COrrelation SpectroscopΥ), 1H-13C-HSQC (Heteronuclear Single Quantum Correlation), HMBC (Heteronuclear Multiple Bond Correlation), NOESY (Nuclear Overhauser Effect SpectroscopY), ROESY (Rotating-frame Overhauser Effect SpectroscopY)] and MS spectral analyses. This is the first report of the natural occurrence of 4-hydroxy-acetophenone 4-O-(3,5-dimethoxy-4-hydroxybenzoyl)-β-d-glucopyranoside. A chemical review on the non-volatile secondary metabolites has been carried out. Based on the literature data, the analysis revealed that the chemical profile of S. willeana is close to that of S. officinalis L. View Full-Text
Keywords: Salvia willeana; 4-hydroxy-acetophenone 4-O-(3,5-dimethoxy-4-hydroxybenzoyl)-β-d-glucopyranoside; megastigmane glucoside; phenolics; terpenes; 2D NMR; Salvia L: chemical review Salvia willeana; 4-hydroxy-acetophenone 4-O-(3,5-dimethoxy-4-hydroxybenzoyl)-β-d-glucopyranoside; megastigmane glucoside; phenolics; terpenes; 2D NMR; Salvia L: chemical review
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Mailis, T.; Skaltsa, H. Polar Constituents of Salvia willeana (Holmboe) Hedge, Growing Wild in Cyprus. Plants 2018, 7, 18.

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