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Plants 2017, 6(2), 16; doi:10.3390/plants6020016

Antimicrobial Resistance and the Alternative Resources with Special Emphasis on Plant-Based Antimicrobials—A Review

1
High Altitude Plant Physiology Research Centre, Hemvati Nandan Bahuguna (H.N.B.) Garhwal University, Srinagar, Garhwal 246174, Uttarakhand, India
2
Department of Microbiology, Bangalore City College, Bangalore 560043, India
3
Department of Microbiology, Institute of Biosciences and Biotechnology, Chhatrapati Shahu Ji Maharaj (C.S.J.M.) University, Kanpur 208024, India
4
Department of Pharmaceutical Chemistry, Hemvati Nandan Bahuguna (H.N.B.) Garhwal University, Srinagar, Garhwal 246174, Uttarakhand, India
*
Authors to whom correspondence should be addressed.
Academic Editor: Milan S. Stankovic
Received: 8 February 2017 / Revised: 20 March 2017 / Accepted: 23 March 2017 / Published: 10 April 2017
(This article belongs to the Special Issue Medicinal Plants and Natural Product Research)
View Full-Text   |   Download PDF [486 KB, uploaded 10 April 2017]   |  

Abstract

Indiscriminate and irrational use of antibiotics has created an unprecedented challenge for human civilization due to microbe’s development of antimicrobial resistance. It is difficult to treat bacterial infection due to bacteria’s ability to develop resistance against antimicrobial agents. Antimicrobial agents are categorized according to their mechanism of action, i.e., interference with cell wall synthesis, DNA and RNA synthesis, lysis of the bacterial membrane, inhibition of protein synthesis, inhibition of metabolic pathways, etc. Bacteria may become resistant by antibiotic inactivation, target modification, efflux pump and plasmidic efflux. Currently, the clinically available treatment is not effective against the antibiotic resistance developed by some bacterial species. However, plant-based antimicrobials have immense potential to combat bacterial, fungal, protozoal and viral diseases without any known side effects. Such plant metabolites include quinines, alkaloids, lectins, polypeptides, flavones, flavonoids, flavonols, coumarin, terpenoids, essential oils and tannins. The present review focuses on antibiotic resistance, the resistance mechanism in bacteria against antibiotics and the role of plant-active secondary metabolites against microorganisms, which might be useful as an alternative and effective strategy to break the resistance among microbes. View Full-Text
Keywords: antibiotic resistance; antimicrobial; mechanism of action; plant metabolite antibiotic resistance; antimicrobial; mechanism of action; plant metabolite
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MDPI and ACS Style

Chandra, H.; Bishnoi, P.; Yadav, A.; Patni, B.; Mishra, A.P.; Nautiyal, A.R. Antimicrobial Resistance and the Alternative Resources with Special Emphasis on Plant-Based Antimicrobials—A Review. Plants 2017, 6, 16.

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