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J. Dev. Biol. 2018, 6(3), 20; https://doi.org/10.3390/jdb6030020

A Potential Role for MMPs during the Formation of Non-Neurogenic Placodes

1
Department of Medical Neuroscience, Dalhousie University, 5850 College Street, Halifax, NS B3H 4R2, Canada
2
Department of Biology, Mount Saint Vincent University, 166 Bedford Highway, Halifax, NS B3M 2J6, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Bryan D. Crawford
Received: 22 June 2018 / Revised: 16 July 2018 / Accepted: 24 July 2018 / Published: 26 July 2018
(This article belongs to the Special Issue Matrix Remodelling during Development)
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Abstract

The formation of non-neurogenic placodes is critical prior to the development of several epithelial derivatives (e.g., feathers, teeth, etc.) and their development frequently involves morphogenetic proteins (or morphogens). Matrix metalloproteinases (MMPs) are important enzymes involved in extracellular matrix remodeling, and recent research has shown that the extracellular matrix (ECM) can modulate morphogen diffusion and cell behaviors. This review summarizes the known roles of MMPs during the development of non-neurogenic structures that involve a placodal stage. Specifically, we discuss feather, hair, tooth, mammary gland and lens development. This review highlights the potential critical role MMPs may play during placode formation in these systems. View Full-Text
Keywords: extracellular matrix; morphogens; embryo; matrix metalloproteases; tooth; lens; mammary gland; feather; hair; β-catenin; patterning extracellular matrix; morphogens; embryo; matrix metalloproteases; tooth; lens; mammary gland; feather; hair; β-catenin; patterning
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Drake, P.M.; Franz-Odendaal, T.A. A Potential Role for MMPs during the Formation of Non-Neurogenic Placodes. J. Dev. Biol. 2018, 6, 20.

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