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J. Dev. Biol., Volume 5, Issue 3 (September 2017)

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Editorial

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Open AccessFeature PaperEditorial Introduction: Drosophila—A Model System for Developmental Biology
J. Dev. Biol. 2017, 5(3), 9; doi:10.3390/jdb5030009
Received: 19 September 2017 / Revised: 20 September 2017 / Accepted: 20 September 2017 / Published: 20 September 2017
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Abstract
Drosophila melanogaster, known colloquially as the fruit fly, remains one of the most commonly used model organisms for biomedical science.[...] Full article
(This article belongs to the Special Issue Drosophila - A Model System for Developmental Biology)

Review

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Open AccessReview The α-Tubulin gene TUBA1A in Brain Development: A Key Ingredient in the Neuronal Isotype Blend
J. Dev. Biol. 2017, 5(3), 8; doi:10.3390/jdb5030008
Received: 1 September 2017 / Revised: 13 September 2017 / Accepted: 18 September 2017 / Published: 19 September 2017
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Abstract
Microtubules are dynamic cytoskeletal polymers that mediate numerous, essential functions such as axon and dendrite growth and neuron migration throughout brain development. In recent years, sequencing has revealed dominant mutations that disrupt the tubulin protein building blocks of microtubules. These tubulin mutations lead
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Microtubules are dynamic cytoskeletal polymers that mediate numerous, essential functions such as axon and dendrite growth and neuron migration throughout brain development. In recent years, sequencing has revealed dominant mutations that disrupt the tubulin protein building blocks of microtubules. These tubulin mutations lead to a spectrum of devastating brain malformations, complex neurological and physical phenotypes, and even fatality. The most common tubulin gene mutated is the α-tubulin gene TUBA1A, which is the most prevalent α-tubulin gene expressed in post-mitotic neurons. The normal role of TUBA1A during neuronal maturation, and how mutations alter its function to produce the phenotypes observed in patients, remains unclear. This review synthesizes current knowledge of TUBA1A function and expression during brain development, and the brain malformations caused by mutations in TUBA1A. Full article
(This article belongs to the Special Issue Development of the Brain in Health and Disease)
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Other

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Open AccessComment A Kinase Duet Performance in the Asymmetric Division of Drosophila Neuroblasts
J. Dev. Biol. 2017, 5(3), 7; doi:10.3390/jdb5030007
Received: 9 September 2017 / Accepted: 12 September 2017 / Published: 14 September 2017
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Abstract
The ability of progenitor stem cells to divide asymmetrically allows for the production of diverse daughter cell fates.[...] Full article
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