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J. Dev. Biol. 2017, 5(1), 3; doi:10.3390/jdb5010003

Canonical Sonic Hedgehog Signaling in Early Lung Development

1
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710‑057 Braga, Portugal
2
ICVS/3B’s-PT Government Associate Laboratory, 4710‑057 Braga/Guimarães, Portugal
3
Department of Pediatric Surgery, Hospital de Braga, 4710‑243 Braga, Portugal
4
Biology Department, School of Sciences, University of Minho, 4710‑057 Braga, Portugal
*
Author to whom correspondence should be addressed.
Academic Editors: Henk Roelink and Simon J. Conway
Received: 26 December 2016 / Revised: 28 February 2017 / Accepted: 8 March 2017 / Published: 13 March 2017
(This article belongs to the Special Issue Hedgehog Signaling in Embryogenesis)
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Abstract

The canonical hedgehog (HH) signaling pathway is of major importance during embryonic development. HH is a key regulatory morphogen of numerous cellular processes, namely, cell growth and survival, differentiation, migration, and tissue polarity. Overall, it is able to trigger tissue-specific responses that, ultimately, contribute to the formation of a fully functional organism. Of all three HH proteins, Sonic Hedgehog (SHH) plays an essential role during lung development. In fact, abnormal levels of this secreted protein lead to severe foregut defects and lung hypoplasia. Canonical SHH signal transduction relies on the presence of transmembrane receptors, such as Patched1 and Smoothened, accessory proteins, as Hedgehog-interacting protein 1, and intracellular effector proteins, like GLI transcription factors. Altogether, this complex signaling machinery contributes to conveying SHH response. Pulmonary morphogenesis is deeply dependent on SHH and on its molecular interactions with other signaling pathways. In this review, the role of SHH in early stages of lung development, specifically in lung specification, primary bud formation, and branching morphogenesis is thoroughly reviewed. View Full-Text
Keywords: Sonic Hedgehog (SHH); lung development; endoderm specification; branching morphogenesis; signaling; transcriptional regulation Sonic Hedgehog (SHH); lung development; endoderm specification; branching morphogenesis; signaling; transcriptional regulation
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Fernandes-Silva, H.; Correia-Pinto, J.; Moura, R.S. Canonical Sonic Hedgehog Signaling in Early Lung Development. J. Dev. Biol. 2017, 5, 3.

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