Differential Cellular Responses to Hedgehog Signalling in Vertebrates—What is the Role of Competence?
AbstractA surprisingly small number of signalling pathways generate a plethora of cellular responses ranging from the acquisition of multiple cell fates to proliferation, differentiation, morphogenesis and cell death. These diverse responses may be due to the dose-dependent activities of signalling factors, or to intrinsic differences in the response of cells to a given signal—a phenomenon called differential cellular competence. In this review, we focus on temporal and spatial differences in competence for Hedgehog (HH) signalling, a signalling pathway that is reiteratively employed in embryos and adult organisms. We discuss the upstream signals and mechanisms that may establish differential competence for HHs in a range of different tissues. We argue that the changing competence for HH signalling provides a four-dimensional framework for the interpretation of the signal that is essential for the emergence of functional anatomy. A number of diseases—including several types of cancer—are caused by malfunctions of the HH pathway. A better understanding of what provides differential competence for this signal may reveal HH-related disease mechanisms and equip us with more specific tools to manipulate HH signalling in the clinic. View Full-Text
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Kiecker, C.; Graham, A.; Logan, M. Differential Cellular Responses to Hedgehog Signalling in Vertebrates—What is the Role of Competence? J. Dev. Biol. 2016, 4, 36.
Kiecker C, Graham A, Logan M. Differential Cellular Responses to Hedgehog Signalling in Vertebrates—What is the Role of Competence? Journal of Developmental Biology. 2016; 4(4):36.Chicago/Turabian Style
Kiecker, Clemens; Graham, Anthony; Logan, Malcolm. 2016. "Differential Cellular Responses to Hedgehog Signalling in Vertebrates—What is the Role of Competence?" J. Dev. Biol. 4, no. 4: 36.
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