Next Article in Journal / Special Issue
The Many Hats of Sonic Hedgehog Signaling in Nervous System Development and Disease
Previous Article in Journal / Special Issue
Yeast Gup1(2) Proteins Are Homologues of the Hedgehog Morphogens Acyltransferases HHAT(L): Facts and Implications
Article Menu

Export Article

Open AccessReview
J. Dev. Biol. 2016, 4(4), 34; doi:10.3390/jdb4040034

Perspectives on Intra- and Intercellular Trafficking of Hedgehog for Tissue Patterning

Centro de Biología Molecular “Severo Ochoa”, Universidad Autónoma de Madrid, CSIC-UAM, Nicolás Cabrera 1, Cantoblanco, 28049 Madrid, Spain
These two authors have equal contribution.
*
Author to whom correspondence should be addressed.
Academic Editors: Henk Roelink and Simon J. Conway
Received: 21 September 2016 / Revised: 7 November 2016 / Accepted: 8 November 2016 / Published: 2 December 2016
(This article belongs to the Special Issue Hedgehog Signaling in Embryogenesis)
View Full-Text   |   Download PDF [1361 KB, uploaded 2 December 2016]   |  

Abstract

Intercellular communication is a fundamental process for correct tissue development. The mechanism of this process involves, among other things, the production and secretion of signaling molecules by specialized cell types and the capability of these signals to reach the target cells in order to trigger specific responses. Hedgehog (Hh) is one of the best-studied signaling pathways because of its importance during morphogenesis in many organisms. The Hh protein acts as a morphogen, activating its targets at a distance in a concentration-dependent manner. Post-translational modifications of Hh lead to a molecule covalently bond to two lipid moieties. These lipid modifications confer Hh high affinity to lipidic membranes, and intense studies have been carried out to explain its release into the extracellular matrix. This work reviews Hh molecule maturation, the intracellular recycling needed for its secretion and the proposed carriers to explain Hh transportation to the receiving cells. Special focus is placed on the role of specialized filopodia, also named cytonemes, in morphogen transport and gradient formation. View Full-Text
Keywords: Hedgehog; cytonemes; gradient formation; pattern formation; modeling Hedgehog; cytonemes; gradient formation; pattern formation; modeling
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Simon, E.; Aguirre-Tamaral, A.; Aguilar, G.; Guerrero, I. Perspectives on Intra- and Intercellular Trafficking of Hedgehog for Tissue Patterning. J. Dev. Biol. 2016, 4, 34.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Dev. Biol. EISSN 2221-3759 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top