Next Article in Journal
Acknowledgement to Reviewers of Journal of Developmental Biology in 2015
Next Article in Special Issue
Restricted Pax3 Deletion within the Neural Tube Results in Congenital Hydrocephalus
Previous Article in Journal / Special Issue
Notochord Cells in Intervertebral Disc Development and Degeneration
Article Menu

Export Article

Open AccessReview
J. Dev. Biol. 2016, 4(1), 4; doi:10.3390/jdb4010004

Cell Fate Decisions During Breast Cancer Development

1
Department of Developmental, Molecular and Chemical Biology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111, USA
2
Raymond and Beverly Sackler Convergence Laboratory, Tufts University School of Medicine, 145 Harrison Ave., Boston, MA 02111, USA
3
Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington St., Boston, MA 02111, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Robert W. Dettman and Andy Wessels
Received: 21 November 2015 / Revised: 11 January 2016 / Accepted: 20 January 2016 / Published: 22 January 2016
(This article belongs to the Special Issue Cell Fate Decisions in Development and Disease)
View Full-Text   |   Download PDF [749 KB, uploaded 22 January 2016]   |  

Abstract

During the formation of breast cancer, many genes become altered as cells evolve progressively from normal to a pre-malignant to a malignant state of growth. How mutations in genes lead to specific subtypes of human breast cancer is only partially understood. Here we review how initial genetic or epigenetic alterations within mammary epithelial cells (MECs) can alter cell fate decisions and put pre-malignant cells on a path towards cancer development with specific phenotypes. Understanding the early stages of breast cancer initiation and progression and how normal developmental processes are hijacked during transformation has significant implications for improving early detection and prevention of breast cancer. In addition, insights gleaned from this understanding may also be important for developing subtype-specific treatment options. View Full-Text
Keywords: breast cancer; cell fate; mammary epithelial cells; plasticity; cancer heterogeneity; mammary gland breast cancer; cell fate; mammary epithelial cells; plasticity; cancer heterogeneity; mammary gland
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Gross, K.; Wronski, A.; Skibinski, A.; Phillips, S.; Kuperwasser, C. Cell Fate Decisions During Breast Cancer Development. J. Dev. Biol. 2016, 4, 4.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Dev. Biol. EISSN 2221-3759 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top