Role of the HPRG Component of Striated Muscle AMP Deaminase in the Stability and Cellular Behaviour of the Enzyme
Abstract
:1. Introduction
2. Distribution and Localization of AMPD Isoforms
3. Human Skeletal Muscle AMPD Deficiency. Correlation between the Level of Enzyme Activity and the Muscle Content of HPRG
4. A Highly Differentiated N-Terminal Region of AMPD Is Produced by Alternative Splicing Events
5. The Inherent N-Terminal Proteolysis of Striated Muscle AMPD Isoforms
6. Importance of Inorganic Phosphate for the Stability of the AMPD-HPRG Complex
7. Intracellular Distribution Data of Striated Muscle AMPD. Evidence of the Interaction of the Enzyme with the Thin Filament
8. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Species | RABBIT | RAT | CHICKEN | |||
---|---|---|---|---|---|---|
Isoform | Reported (kDa) | Predicted (kDa) | Reported (kDa) | Predicted (kDa) | Reported (kDa) | Predicted (kDa) |
AMPD1 (M) | 80–85 a 68 b–70 c | 86 | 60 d 68 e–70 f | 86.3–85.9 | 69 b–70 c | 85.1–85.6 |
AMPD3 (E) | 80–81 g | 93.9 | n.d. | 88.4–92 | 69 h–70 i | 88.8–93.6 |
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Ronca, F.; Raggi, A. Role of the HPRG Component of Striated Muscle AMP Deaminase in the Stability and Cellular Behaviour of the Enzyme. Biomolecules 2018, 8, 79. https://doi.org/10.3390/biom8030079
Ronca F, Raggi A. Role of the HPRG Component of Striated Muscle AMP Deaminase in the Stability and Cellular Behaviour of the Enzyme. Biomolecules. 2018; 8(3):79. https://doi.org/10.3390/biom8030079
Chicago/Turabian StyleRonca, Francesca, and Antonio Raggi. 2018. "Role of the HPRG Component of Striated Muscle AMP Deaminase in the Stability and Cellular Behaviour of the Enzyme" Biomolecules 8, no. 3: 79. https://doi.org/10.3390/biom8030079