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Biomolecules 2018, 8(3), 72; https://doi.org/10.3390/biom8030072

Intrinsic Iron Release Is Associated with Lower Mortality in Patients with Stable Coronary Artery Disease—First Report on the Prospective Relevance of Intrinsic Iron Release

1
Department of General and Interventional Cardiology, University Heart Center Hamburg, 20246 Hamburg, Germany
2
German Center for Cardiovascular Research (DZHK), Partner Site Hamburg, Lübeck, Kiel, 20246 Hamburg, Germany
3
German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, 55131 Mainz, Germany
4
Department of Laboratory Medicine, University Medical Center, Johannes Gutenberg University Mainz, 55131 Mainz, Germany
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 9 July 2018 / Revised: 3 August 2018 / Accepted: 3 August 2018 / Published: 9 August 2018
(This article belongs to the Special Issue Biomolecules for Translational Approaches in Cardiology)
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Abstract

Intrinsic iron release is discussed to have favorable effects in coronary artery disease (CAD). The aim of this study was to evaluate the prognostic relevance of intrinsic iron release in patients with CAD. Intrinsic iron release was based on a definition including hepcidin and soluble transferrin receptor (sTfR). In a cohort of 811 patients with angiographically documented CAD levels of hepcidin and sTfR were measured at baseline. Systemic body iron release was defined as low levels of hepcidin (<24 ng/mL) and high levels of sTfR (≥2 mg/L). A commercially available ELISA (DRG) was used for measurements of serum hepcidin. Serum sTfR was determined by using an automated immunoassay (). Cardiovascular mortality was the main outcome measure. The criteria of intrinsic iron release were fulfilled in 32.6% of all patients. Significantly lower cardiovascular mortality rates were observed in CAD patients with systemic iron release. After adjustment for body mass index, smoking status, hypertension, diabetes, dyslipidemia, sex, and age, the hazard ratio for future cardiovascular death was 0.41. After an additional adjustment for surrogates of the size of myocardial necrosis (troponin I), anemia (hemoglobin), and cardiac function and heart failure severity (N-terminal pro B-type natriuretic peptide), this association did not change (Hazard ratio 0.37 (95% confidence interval 0.14–0.99), p = 0.047). In conclusion, significantly lower cardiovascular mortality rates were observed in CAD patients with intrinsic iron release shown during follow-up. View Full-Text
Keywords: iron release; coronary artery disease; biomarker; prognosis; hepcidin iron release; coronary artery disease; biomarker; prognosis; hepcidin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Ruhe, J.; Waldeyer, C.; Ojeda, F.; Altay, A.; Schnabel, R.B.; Schäfer, S.; Lackner, K.J.; Blankenberg, S.; Zeller, T.; Karakas, M. Intrinsic Iron Release Is Associated with Lower Mortality in Patients with Stable Coronary Artery Disease—First Report on the Prospective Relevance of Intrinsic Iron Release. Biomolecules 2018, 8, 72.

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