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Biomolecules 2018, 8(2), 41; https://doi.org/10.3390/biom8020041

Pinocembrin–Lecithin Complex: Characterization, Solubilization, and Antioxidant Activities

Key Laboratory of Food Nutrition and Safety, Ministry of Education, School of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
These authors contributed equally to the work.
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Received: 14 May 2018 / Revised: 14 June 2018 / Accepted: 18 June 2018 / Published: 19 June 2018
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Abstract

Pinocembrin is a natural flavonoid compound which is capable of antioxidant, antibacterial, anti-inflammatory, and antineoplastic activities. The present study aimed to enhance the solubility and antioxidant activities of pinocembrin by complex formation with lecithin. The physicochemical characteristics of pinocembrin–lecithin complex were analyzed by ultraviolet (UV), fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and solubility assay, and the antioxidant activities of pinocembrin–lecithin complex were evaluated via radical scavenging capacities for 2,2′-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS), hydroxyl, and superoxide-anion. The results indicated that pinocembrin complex with lecithin could significantly improve the solubility of pinocembrin in water and n-octane, the pinocembrin–lecithin complex displayed no characteristic endothermic peak and the appearance of amorphous state, compared to the pinocembrin, and no new covalent bond was produced in the pinocembrin and lecithin compound. It was demonstrated that the antioxidant activities of pinocembrin were obviously enhanced by the complex with lecithin, and the scavenging capacities for hydroxyl radical, DPPH, superoxide-anion radical, and ABTS radical of pinocembrin–lecithin complex were 82.44 ± 2.21%, 40.07 ± 1.32%, 59.15 ± 0.86%, and 24.73 ± 1.04% at 1.0 mg/mL, respectively. It suggested that the pinocembrin–lecithin complex had a great potential application prospect in the healthcare industry and in clinical practice. View Full-Text
Keywords: pinocembrin–lecithin complex; solubility pinocembrin–lecithin complex; solubility
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Yang, X.; Wang, X.; Chen, X.-Y.; Ji, H.-Y.; Zhang, Y.; Liu, A.-J. Pinocembrin–Lecithin Complex: Characterization, Solubilization, and Antioxidant Activities. Biomolecules 2018, 8, 41.

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