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Biomolecules 2018, 8(2), 34; https://doi.org/10.3390/biom8020034

Metabolomics in Radiation-Induced Biological Dosimetry: A Mini-Review and a Polyamine Study

1
Biotechnology Research Division, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), 29, Geumgu-gil, Jeongeup-si, Jeonbuk 56212, Korea
2
Radiation Biotechnology and Applied Radioisotope Science, University of Science Technology (UST), 217 Gajeong-ro, Daejeon 34113, Korea
Received: 5 April 2018 / Revised: 18 May 2018 / Accepted: 25 May 2018 / Published: 29 May 2018
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Abstract

In this study, we elucidate that polyamine metabolite is a powerful biomarker to study post-radiation changes. Metabolomics in radiation biodosimetry, the application of a metabolomics analysis to the field of radiobiology, promises to increase the understanding of biological responses by ionizing radiation (IR). Radiation exposure triggers a complex network of molecular and cellular responses that impacts metabolic processes and alters the levels of metabolites. Such metabolites have potential as biomarkers for radiation dosimetry. Among metabolites, polyamine is one of many potential biomarkers to estimate radiation response. In addition, this review provides an opportunity for the understanding of a radiation metabolomics in biodosimetry and a polyamine case study. View Full-Text
Keywords: ionizing radiation; polyamines; metabolomics; radiation biodosimetry; biomarker ionizing radiation; polyamines; metabolomics; radiation biodosimetry; biomarker
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Roh, C. Metabolomics in Radiation-Induced Biological Dosimetry: A Mini-Review and a Polyamine Study. Biomolecules 2018, 8, 34.

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