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Biomolecules 2018, 8(1), 8; https://doi.org/10.3390/biom8010008

Elsinopirins A–D, Decalin Polyketides from the Ascomycete Elsinoё pyri

1
Microbial Drugs, Helmholtz Centre for Infection Research GmbH (HZI), Inhoffenstraße 7, 38124 Braunschweig, Germany
2
German Centre for Infection Research Association (DZIF), Partner Site Hannover-Braunschweig, Inhoffenstraße 7, 38124 Braunschweig, Germany
3
Institute of Biochemical Engineering, Technical University Braunschweig, Rebenring 56, 38106 Braunschweig, Germany
4
Agricultural Institute of Slovenia, Hacquetova ulica 17, 1000 Ljubljana, Slovenia
*
Author to whom correspondence should be addressed.
Received: 29 December 2017 / Revised: 24 January 2018 / Accepted: 30 January 2018 / Published: 5 February 2018
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Abstract

In course of our screening for new secondary metabolites from ecological niche specialized, phytopathogenic fungi, the plant pathogen Elsinoё pyri, strain 2203C, was found to produce four novel compounds (14), which were named elsinopirins A–D, in addition to the known metabolite elsinochrome A (5). After isolation by preparative high-performance liquid chromatography (HPLC), their structures, including relative stereochemistry, were elucidated by 1D and 2D nuclear magnetic resonance (NMR) and mass spectrometry (MS) data. Finally, absolute stereochemistry was assigned by chemical shifts of Mosher’s esters (α-methoxy-α-trifluoromethylphenylacetic acid; MTPA) derivatives of elsinopirin B (2). The compounds were found to be devoid of significant antibacterial, antifungal, and cytotoxic activities. View Full-Text
Keywords: secondary metabolites; polyketides; structure elucidation; decalin secondary metabolites; polyketides; structure elucidation; decalin
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Surup, F.; Pommerehne, K.; Schroers, H.-J.; Stadler, M. Elsinopirins A–D, Decalin Polyketides from the Ascomycete Elsinoё pyri. Biomolecules 2018, 8, 8.

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