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Biomolecules 2017, 7(1), 9; doi:10.3390/biom7010009

Key Events Participating in the Pathogenesis of Alcoholic Liver Disease

Department of Pathology, University of Illinois at Chicago, 840 S. Wood St., Suite 130 CSN, MC 847, Chicago, IL 60612, USA
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Received: 21 December 2016 / Accepted: 20 January 2017 / Published: 27 January 2017
(This article belongs to the Collection Multi-Organ Alcohol-Related Damage: Mechanisms and Treatment)
View Full-Text   |   Download PDF [1376 KB, uploaded 4 February 2017]   |  

Abstract

Alcoholic liver disease (ALD) is a leading cause of morbidity and mortality worldwide. It ranges from fatty liver to steatohepatitis, fibrosis, cirrhosis and hepatocellular carcinoma.The most prevalent forms of ALD are alcoholic fatty liver, alcoholic hepatitis (AH) and alcoholic cirrhosis, which frequently progress as people continue drinking. ALD refers to a number of symptoms/deficits that contribute to liver injury. These include steatosis, inflammation, fibrosis and cirrhosis, which, when taken together, sequentially or simultaneously lead to significant disease progression. The pathogenesis of ALD, influenced by host and environmental factors, is currentlyonly partially understood. To date, lipopolysaccharide (LPS) translocation from the gut to the portal blood, aging, gender, increased infiltration and activation of neutrophils and bone marrow-derived macrophages along with alcohol plus iron metabolism, with its associated increase in reactive oxygen species (ROS), are all key events contributing to the pathogenesis of ALD. This review aimsto introduce the reader to the concept of alcohol‐mediated liver damage and the mechanisms driving injury. View Full-Text
Keywords: damage‐associated  molecular  patterns;  inflammasome;  iron;  lipid  peroxidation;  macrophages; neutrophils; pathogen‐associated molecular patterns damage‐associated  molecular  patterns;  inflammasome;  iron;  lipid  peroxidation;  macrophages; neutrophils; pathogen‐associated molecular patterns
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Magdaleno, F.; Blajszczak, C.C.; Nieto, N. Key Events Participating in the Pathogenesis of Alcoholic Liver Disease. Biomolecules 2017, 7, 9.

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