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Biomolecules 2016, 6(1), 3; doi:10.3390/biom6010003

Targeting Stromal-Cancer Cell Crosstalk Networks in Ovarian Cancer Treatment

1
Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
2
Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Weill Cornell Medical College, Houston, TX 77030, USA
3
National Cancer Institute Center for Modeling Cancer Development, Houston Methodist Research Institute, Houston, TX 77030, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editors: Maria Barbolina and Jürg Bähler
Received: 9 October 2015 / Revised: 20 November 2015 / Accepted: 9 December 2015 / Published: 6 January 2016
(This article belongs to the Special Issue Signal Transduction Pathways in Gynecologic Malignancies)
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Abstract

Ovarian cancer is a histologically, clinically, and molecularly diverse disease with a five-year survival rate of less than 30%. It has been estimated that approximately 21,980 new cases of epithelial ovarian cancer will be diagnosed and 14,270 deaths will occur in the United States in 2015, making it the most lethal gynecologic malignancy. Ovarian tumor tissue is composed of cancer cells and a collection of different stromal cells. There is increasing evidence that demonstrates that stromal involvement is important in ovarian cancer pathogenesis. Therefore, stroma-specific signaling pathways, stroma-derived factors, and genetic changes in the tumor stroma present unique opportunities for improving the diagnosis and treatment of ovarian cancer. Cancer-associated fibroblasts (CAFs) are one of the major components of the tumor stroma that have demonstrated supportive roles in tumor progression. In this review, we highlight various types of signaling crosstalk between ovarian cancer cells and stromal cells, particularly with CAFs. In addition to evaluating the importance of signaling crosstalk in ovarian cancer progression, we discuss approaches that can be used to target tumor-promoting signaling crosstalk and how these approaches can be translated into potential ovarian cancer treatment. View Full-Text
Keywords: ovarian cancer; cancer-associated fibroblasts; stromal-tumor crosstalk; tumor microenvironment ovarian cancer; cancer-associated fibroblasts; stromal-tumor crosstalk; tumor microenvironment
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yeung, T.-L.; Leung, C.S.; Li, F.; Wong, S.T.C.; Mok, S.C. Targeting Stromal-Cancer Cell Crosstalk Networks in Ovarian Cancer Treatment. Biomolecules 2016, 6, 3.

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