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Volume 9
Issue 10
10.3390/metabo9100213
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Article
Peer-Review Record

Reactive Carbonyl Species as Potential Pro-Oxidant Factors Involved in Lichen Planus Pathogenesis

Metabolites 2019, 9(10), 213; https://doi.org/10.3390/metabo9100213
by Madalina Irina Mitran 1,2, Ilinca Nicolae 3, Mircea Tampa 3,4,*, Cristina Iulia Mitran 1,2, Constantin Caruntu 5,6,*, Maria Isabela Sarbu 4, Corina Daniela Ene 7, Clara Matei 4, Simona Roxana Georgescu 3,4,* and Mircea Ioan Popa 1,2
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Metabolites 2019, 9(10), 213; https://doi.org/10.3390/metabo9100213
Submission received: 28 August 2019 / Revised: 20 September 2019 / Accepted: 1 October 2019 / Published: 3 October 2019
(This article belongs to the Special Issue Metabolomics in the Study of Disease)

Round 1

Reviewer 1 Report

Although the findings are not too surprising, the paper adds some potentially interesting aspects to the pathophysiology of lichen planus.

The TBARS-method, however,  is questionable as for many aspects. Therefore, the authors should add data of another independent method for MDA and also for total antioxidant status.

The potential role of oxidized phospholipids comprising also carbonyl species has not been addressed and should be included into the discussion (e.g. Deigner/Hermetter, Current Opinion in Lipidology, June 2008, Vol. 19)

Author Response

Please see the attachment

Author Response File: Author Response.docx

Reviewer 2 Report

In this work, Mitran and co-authors measured serum levels of 4-HNE and MDA in patients affected by cutaneous lichen planus. Since 4-HNE and MDA are by-products of the majority RCGs, authors considered them as representative indicators of lipid peroxidation rate in patients. Authors reported a statistically significant increase of 4-HNE and MDA in patients with respect to controls. Moreover, they reported that 4-HNE and MDA values inversely correlate with TAS in patients.

The work is well presented and the manuscript clearly written.

 

Major concerns

As the authors pointed out, their findings are not completely novel in the field of cutaneous lichen planus research. Moreover, the study was conducted on a limited number of patients.

They should increase the relevance of the study.

A possibility is to report the serum levels of some component of TAS, such as folic acid or vitamin B12, as previously done by other authors for oral lichen planus patients.

In addition, authors might report about other parameters considered associated with lichen planus pathogenesis, such as iron status.

 

Minor concerns

Authors should report whether a correlation between TAS and 4-HNE (and/or MDA) levels exists in controls.

Methods description can be improved

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

the paper has improved after revision

Reviewer 2 Report

I have no additional comments

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