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Cancer Metabolomics and the Human Metabolome Database
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Metabolites 2016, 6(1), 11; doi:10.3390/metabo6010011

Evaluation of Cancer Metabolomics Using ex vivo High Resolution Magic Angle Spinning (HRMAS) Magnetic Resonance Spectroscopy (MRS)

Departments of Radiology and Pathology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, CNY-6, Charlestown, MA 02129, USA
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Academic Editors: Claudiu T. Supuran and Natalie Serkova
Received: 25 January 2016 / Revised: 15 March 2016 / Accepted: 17 March 2016 / Published: 22 March 2016
(This article belongs to the Special Issue Cancer Metabolomics 2016)
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Abstract

According to World Health Organization (WHO) estimates, cancer is responsible for more deaths than all coronary heart disease or stroke worldwide, serving as a major public health threat around the world. High resolution magic angle spinning (HRMAS) magnetic resonance spectroscopy (MRS) has demonstrated its usefulness in the identification of cancer metabolic markers with the potential to improve diagnosis and prognosis for the oncology clinic, due partially to its ability to preserve tissue architecture for subsequent histological and molecular pathology analysis. Capable of the quantification of individual metabolites, ratios of metabolites, and entire metabolomic profiles, HRMAS MRS is one of the major techniques now used in cancer metabolomic research. This article reviews and discusses literature reports of HRMAS MRS studies of cancer metabolomics published between 2010 and 2015 according to anatomical origins, including brain, breast, prostate, lung, gastrointestinal, and neuroendocrine cancers. These studies focused on improving diagnosis and understanding patient prognostication, monitoring treatment effects, as well as correlating with the use of in vivo MRS in cancer clinics. View Full-Text
Keywords: metabolomics; high-resolution magic angle spinning (HRMAS); magnetic resonance spectroscopy (MRS); cancer metabolomics; high-resolution magic angle spinning (HRMAS); magnetic resonance spectroscopy (MRS); cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Fuss, T.L.; Cheng, L.L. Evaluation of Cancer Metabolomics Using ex vivo High Resolution Magic Angle Spinning (HRMAS) Magnetic Resonance Spectroscopy (MRS). Metabolites 2016, 6, 11.

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