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Metformin: On Ongoing Journey across Diabetes, Cancer Therapy and Prevention
Molecular Chemoprevention Group, Molecular Medicine Area, Regina Elena National Institute, Rome 00144, Italy
Department of Oncology, Juravinski Cancer Center, McMaster University, Hamilton, ON L8V 5C2, Canada
Translational Oncogenomics Unit-ROC, Molecular Medicine Area, Regina Elena National Institute, Rome 00144, Italy
* Author to whom correspondence should be addressed.
Received: 10 July 2013; in revised form: 27 September 2013 / Accepted: 31 October 2013 / Published: 7 November 2013
Abstract: Cancer metabolism is the focus of intense research, which witnesses its key role in human tumors. Diabetic patients treated with metformin exhibit a reduced incidence of cancer and cancer-related mortality. This highlights the possibility that the tackling of metabolic alterations might also hold promising value for treating cancer patients. Here, we review the emerging role of metformin as a paradigmatic example of an old drug used worldwide to treat patients with type II diabetes which to date is gaining strong in vitro and in vivo anticancer activities to be included in clinical trials. Metformin is also becoming the focus of intense basic and clinical research on chemoprevention, thus suggesting that metabolic alteration is an early lesion along cancer transformation. Metabolic reprogramming might be a very efficient prevention strategy with a profound impact on public health worldwide.
Keywords: diabetes; cancer; microRNA; therapy; chemoprevention; metabolism; meta analysis
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Pulito, C.; Sanli, T.; Rana, P.; Muti, P.; Blandino, G.; Strano, S. Metformin: On Ongoing Journey across Diabetes, Cancer Therapy and Prevention. Metabolites 2013, 3, 1051-1075.
Pulito C, Sanli T, Rana P, Muti P, Blandino G, Strano S. Metformin: On Ongoing Journey across Diabetes, Cancer Therapy and Prevention. Metabolites. 2013; 3(4):1051-1075.
Pulito, Claudio; Sanli, Toran; Rana, Punam; Muti, Paola; Blandino, Giovanni; Strano, Sabrina. 2013. "Metformin: On Ongoing Journey across Diabetes, Cancer Therapy and Prevention." Metabolites 3, no. 4: 1051-1075.