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Optimality Principles in the Regulation of Metabolic Networks
Systems Bioinformatics, AIMMS, VU University, 1081 HV, Amsterdam, The Netherlands
Kluyver Centre for Genomics of Industrial Fermentation/NCSB, 2600 GA, Delft, The Netherlands
Regulatory Networks Group, Netherlands Institute of Systems Biology, Amsterdam, The Netherlands
Life Sciences, Centre for Mathematics and Computer Science (CWI), 1098 XG Amsterdam, The Netherlands
* Author to whom correspondence should be addressed.
Received: 20 July 2012; in revised form: 15 August 2012 / Accepted: 17 August 2012 / Published: 29 August 2012
Abstract: One of the challenging tasks in systems biology is to understand how molecular networks give rise to emergent functionality and whether universal design principles apply to molecular networks. To achieve this, the biophysical, evolutionary and physiological constraints that act on those networks need to be identified in addition to the characterisation of the molecular components and interactions. Then, the cellular “task” of the network—its function—should be identified. A network contributes to organismal fitness through its function. The premise is that the same functions are often implemented in different organisms by the same type of network; hence, the concept of design principles. In biology, due to the strong forces of selective pressure and natural selection, network functions can often be understood as the outcome of fitness optimisation. The hypothesis of fitness optimisation to understand the design of a network has proven to be a powerful strategy. Here, we outline the use of several optimisation principles applied to biological networks, with an emphasis on metabolic regulatory networks. We discuss the different objective functions and constraints that are considered and the kind of understanding that they provide.
Keywords: metabolic regulatory networks; optimal regulation; systems biology; design principles
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MDPI and ACS Style
Berkhout, J.; Bruggeman, F.J.; Teusink, B. Optimality Principles in the Regulation of Metabolic Networks. Metabolites 2012, 2, 529-552.
Berkhout J, Bruggeman FJ, Teusink B. Optimality Principles in the Regulation of Metabolic Networks. Metabolites. 2012; 2(3):529-552.
Berkhout, Jan; Bruggeman, Frank J.; Teusink, Bas. 2012. "Optimality Principles in the Regulation of Metabolic Networks." Metabolites 2, no. 3: 529-552.