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Metabolites 2012, 2(3), 529-552; doi:10.3390/metabo2030529

Optimality Principles in the Regulation of Metabolic Networks

1,2,* , 1,3,4 and 1,2,3
Received: 20 July 2012 / Revised: 15 August 2012 / Accepted: 17 August 2012 / Published: 29 August 2012
(This article belongs to the Special Issue Metabolism and Systems Biology)
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Abstract: One of the challenging tasks in systems biology is to understand how molecular networks give rise to emergent functionality and whether universal design principles apply to molecular networks. To achieve this, the biophysical, evolutionary and physiological constraints that act on those networks need to be identified in addition to the characterisation of the molecular components and interactions. Then, the cellular “task” of the network—its function—should be identified. A network contributes to organismal fitness through its function. The premise is that the same functions are often implemented in different organisms by the same type of network; hence, the concept of design principles. In biology, due to the strong forces of selective pressure and natural selection, network functions can often be understood as the outcome of fitness optimisation. The hypothesis of fitness optimisation to understand the design of a network has proven to be a powerful strategy. Here, we outline the use of several optimisation principles applied to biological networks, with an emphasis on metabolic regulatory networks. We discuss the different objective functions and constraints that are considered and the kind of understanding that they provide.
Keywords: metabolic regulatory networks; optimal regulation; systems biology; design principles metabolic regulatory networks; optimal regulation; systems biology; design principles
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Berkhout, J.; Bruggeman, F.J.; Teusink, B. Optimality Principles in the Regulation of Metabolic Networks. Metabolites 2012, 2, 529-552.

AMA Style

Berkhout J, Bruggeman FJ, Teusink B. Optimality Principles in the Regulation of Metabolic Networks. Metabolites. 2012; 2(3):529-552.

Chicago/Turabian Style

Berkhout, Jan; Bruggeman, Frank J.; Teusink, Bas. 2012. "Optimality Principles in the Regulation of Metabolic Networks." Metabolites 2, no. 3: 529-552.

Metabolites EISSN 2218-1989 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert