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Scientia Pharmaceutica, Volume 85, Issue 4

2017 December - 4 articles

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Articles (4)

  • Article
  • Open Access
3 Citations
4,002 Views
9 Pages
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Theoretical Investigation of the Enantioselective Complexations between pfDHFR and Cycloguanil Derivatives

  • Suriyawut Kulatee,
  • Pisanu Toochinda,
  • Anotai Suksangpanomrung and
  • Luckhana Lawtrakul
Sci. Pharm.2017, 85(4), 37;https://doi.org/10.3390/scipharm85040037

21 November 2017

Point mutations in Plasmodium falciparum dihydrofolate reductase (pfDHFR), especially the double mutant variant (A16V + S108T), led to ineffective inhibiting by cycloguanil (Cyc). Cycloguanil derivatives showed good inhibiting properties against wild...

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  • Article
  • Open Access
74 Citations
7,742 Views
9 Pages
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Leishmanicidal Activity of Biogenic Fe3O4 Nanoparticles

  • Mehrdad Khatami,
  • Hajar Alijani,
  • Iraj Sharifi,
  • Fatemeh Sharifi,
  • Shahram Pourseyedi,
  • Sam Kharazi,
  • Marcos Augusto Lima Nobre and
  • Manouchehr Khatami
Sci. Pharm.2017, 85(4), 36;https://doi.org/10.3390/scipharm85040036

20 November 2017

Abstract: Due to the multiplicity of useful applications of metal oxide nanoparticles (ONPs) in medicine are growing exponentially, in this study, Fe3O4 (iron oxide) nanoparticles (IONPs) were biosynthesized using Rosemary to evaluate the leishmanici...

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  • Article
  • Open Access
15 Citations
4,746 Views
12 Pages
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Hydrogen Sulfide Releasing 2-Mercaptoacrylic Acid-Based Derivative Possesses Cytoprotective Activity in a Small Intestine of Rats with Medication-Induced Enteropathy

  • Yulia Sklyarova,
  • Iryna Fomenko,
  • Iryna Lozynska,
  • Andrii Lozynskyi,
  • Roman Lesyk and
  • Alexandr Sklyarov
Sci. Pharm.2017, 85(4), 35;https://doi.org/10.3390/scipharm85040035

24 October 2017

Small intestinal injury is known to be one of the most commonly appearing pathologies, resulting in the use of medications such as: nonsteroidal anti-inflammatory drugs (NSAIDs), antitumor drugs and angiotensin-converting enzyme (ACE) inhibitors. The...

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  • Article
  • Open Access
10 Citations
4,044 Views
16 Pages
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Antimycobacterial Activities of N-Substituted-Glycinyl 1H-1,2,3-Triazolyl Oxazolidinones and Analytical Method Development and Validation for a Representative Compound

  • Naser F. Al-Tannak and
  • Oludotun A. Phillips
Sci. Pharm.2017, 85(4), 34;https://doi.org/10.3390/scipharm85040034

2 October 2017

Twelve N-substituted-glycinyl triazolyl oxazolidinone derivatives were screened for antimycobacterial activity against susceptible (Mycobacterium tuberculosis (Mtb) H37Rv) and resistant (isoniazid (INH)-resistant Mtb (SRI 1369), rifampin (RMP)-resist...

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