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Sci. Pharm. 2015, 83(3), 501-510; doi:10.3797/scipharm.1409-07

Improved Pharmacokinetics of Aceclofenac Immediate Release Tablets Incorporating its Inclusion Complex with Hydroxypropyl-β-Cyclodextrin

1
Department of Pharmaceutics, Globus College of Pharmacy, Bangrasia, Bhopal-462045, MP, India
2
Department of Pharmaceutics, IPS College of Pharmacy, Gwalior, MP, India
3
Department of Pharmaceutics, Rajiv Academy for Pharmacy, Chhattikara, Mathura, UP, India
*
Author to whom correspondence should be addressed.
Received: 10 September 2014 / Accepted: 2 February 2015 / Published: 2 February 2015
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Abstract

The present investigation reports the various pharmacokinetic parameters of immediate release aceclofenac tablets incorporating its inclusion complex with hydroxypropyl-β-cyclodextrin. The tablets were prepared using aceclofenac: hydroxypropyl-β-cyclodextrin in a 1:1 molar ratio by the direct compression method (TKN). The results were compared with those of the marketed brand (MKT) and pure drug (TAC). The P-values indicated that mean plasma concentrations were significantly different among all three formulations administered (P<0.05, P<0.01). TKN showed significantly higher plasma levels when compared to the pure drug (P<0.01). The Cmax and AUC(0-∞) of TKN were significantly higher (P<0.05) compared to the pure drug and marketed formulation. Furthermore, the first-order overall elimination rate constant (Kel) of TKN was also significantly higher (P<0.05) compared to the pure drug and its marketed formulation. These results suggested that tablets prepared by incorporating the AC-HPβCD inclusion complex (TKN) would provide a more rapid onset of pharmacological effects in comparison to the marketed formulation and pure drug.
Keywords: Inclusion complex; Immediate release tablets; Bioavailability; In vivo studies; Pharmacokinetic parameters Inclusion complex; Immediate release tablets; Bioavailability; In vivo studies; Pharmacokinetic parameters
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

DAHIYA, S.; KAUSHIK, A.; PATHAK, K. Improved Pharmacokinetics of Aceclofenac Immediate Release Tablets Incorporating its Inclusion Complex with Hydroxypropyl-β-Cyclodextrin. Sci. Pharm. 2015, 83, 501-510.

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