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Sci. Pharm. 2014, 82(4), 735-748; doi:10.3797/scipharm.1405-04

New p-Substituted Salicylaldehyde Phenylhydrazone Derivatives: Synthesis, Characterization, and Antioxidant Activities

1
Department of Organic Chemistry, Faculty of Arts and Sciences, Yildiz Technical University, 34210, Esenler/Istanbul, Turkey
2
Department of Biochemistry, Faculty of Arts and Sciences, Yildiz Technical University, 34210, Esenler/Istanbul, Turkey
*
Author to whom correspondence should be addressed.
Received: 8 May 2014 / Accepted: 1 July 2014 / Published: 1 July 2014
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Abstract

A series of new p-nitrophenylhydrazone derivatives 3a–f were synthesized, characterized, and investigated for their antioxidant activities. These com-pounds have been synthesized by refluxing (p-nitrophenyl)hydrazine with 4-sub-stituted salicylaldehydes. The structures of the compounds were established by IR, 1H- and 13C-NMR, and MS data. The antioxidant activities (free radical-scavenging activity, reducing power, metal chelating activity, and total anti-oxidant activity) of the hydrazone compounds were evaluated. All of the compounds exhibited significant activities, while compound 3a, with the shortest chain, showed the highest antioxidant activity in all of the tests.
Keywords: Antioxidant activity; Metal chelating activity; Phenylhydrazones; Radical scavenging activity; Reducing power; Total antioxidant activity Antioxidant activity; Metal chelating activity; Phenylhydrazones; Radical scavenging activity; Reducing power; Total antioxidant activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

YORUR-GORECI, C.; ALTAS-KIYMAZ, N.; PEKSEL, A.; BILGIN-ERAN, B.; SONMEZ, M. New p-Substituted Salicylaldehyde Phenylhydrazone Derivatives: Synthesis, Characterization, and Antioxidant Activities. Sci. Pharm. 2014, 82, 735-748.

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