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Sci. Pharm. 2013, 81(1), 223-232; doi:10.3797/scipharm.1209-18

Inhibitions of Several Antineoplastic Drugs on Serum Sialic Acid Levels in Mice Bearing Tumors

1
School of Life Sciences, Shanghai University, Shanghai 200444, PR China
2
College of Science, Shanghai University, Shanghai 200444, PR China
3
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China
*
Author to whom correspondence should be addressed.
Received: 27 September 2012 / Accepted: 14 November 2012 / Published: 14 November 2012
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Abstract

Six murine tumors, including ascetic tumors HepA, EC, P388 leukemia, S180 and solid tumor S180, and Lewis lung carcinoma, were employed in this work. The free sialic acid concentrations in both blood and ascites were measured in tumor-bearing mice. The results showed that the content of sialic acids in blood was increased in tumor growth and certain tumor types. Higher sialic acid content was observed in ascites than that present in blood. The influence of antineoplastic agents (vincristine, thiotepa, adriamycin, probimane, cisplatin, oxalysine, cortisone, nitrogen mustard, lycobetaine, Ara-C, harringtonine, and cyclophosphamide) on the content of sialic acids in mice blood bearing solid tumors of either S180 or Lewis lung carcinoma was observed. Different inhibitions of antineoplastic drugs on both tumor growth and serum sialic acid levels in mice bearing tumors were found. Among these antineoplastic drugs, probimane, cisplatin, nitrogen mustard, and lycobetaine were able to decrease the serum sialic acid levels in mice bearing tumors. Since these four antineoplastic drugs are all DNA chelating agents, it was proposed that the inhibition of tumor sialic acids by these drugs might be through the DNA template via two ways. Since we have found no effect of antineoplastic drugs on serum sialic acid levels in normal mice, this suggests that the inhibition of antineoplastic drugs on sialic acids is by tumor involvement.
Keywords: Sialic acids; Antineoplastic drugs; Neoplasm metastasis; Cancer therapy; Probimane; Cisplatin; Nitrogen mustard; Lycobetaine Sialic acids; Antineoplastic drugs; Neoplasm metastasis; Cancer therapy; Probimane; Cisplatin; Nitrogen mustard; Lycobetaine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

LU, D.-Y.; XU, J.; LU, T.-R.; WU, H.-Y.; XU, B. Inhibitions of Several Antineoplastic Drugs on Serum Sialic Acid Levels in Mice Bearing Tumors. Sci. Pharm. 2013, 81, 223-232.

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