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Sci. Pharm. 2013, 81(1), 211-222; doi:10.3797/scipharm.1208-17

Antidepressant Effect of Aminophylline After Ethanol Exposure

1
Departament of Physiology and Pharmacology, Federal University of Ceará, Rua Cel. Nunes de Melo 1127, CEP 60431-270, Fortaleza, Ceará, Brazil
2
Superior Institute of Biomedical Sciences, Academic Master in Physiological Sciences, State University of Ceará, Av. Paranjana 1700, CEP 60740-000, Campus do Itaperi, Fortaleza, Ceará, Brazil
3
Christus Medicine Faculty, Rua Israel Bezerra 630, CEP 60135-460, Fortaleza, Ceará, Brazil
*
Author to whom correspondence should be addressed.
Received: 30 August 2012 / Accepted: 23 October 2012 / Published: 23 October 2012
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Abstract

This work investigated the association of acute ethanol and aminophylline administration on behavioral models of depression and prefrontal monoamine levels (i.e. norepinephrine and dopamine) in mice. The animals received a single dose of ethanol (2 g/kg) or aminophylline (5 or 10 mg/kg) alone or in association. Thirty minutes after the last drug administration, the animals were assessed in behavioral models by the forced swimming and tail suspension tests. After these tests, the animals were sacrificed and the prefrontal cortices dissected to measure monoamine content. Results showed that ethanol presented depression-like activity in the forced swimming and tail suspension tests. These effects were reversed by the association with aminophylline in all tests. Norepinephrine and dopamine levels decreased, while an increase in the dopamine metabolite, (4-hydroxy-3-methoxyphenyl)acetic acid (DOPAC), after ethanol administration was observed. On the contrary, the association of ethanol and aminophylline increased the norepinephrine and dopamine content, while it decreased DOPAC when compared to the ethanol group, confirming the alterations observed in the behavioral tests. These data reinforce the involvement of the adenosinergic system on ethanol effects, highlighting the importance of the norepinephrine and dopamine pathways in the prefrontal cortex to the effects of ethanol.
Keywords: Adenosine; Ethanol; Aminophylline; Monoamines; Behavior; Prefrontal cortex Adenosine; Ethanol; Aminophylline; Monoamines; Behavior; Prefrontal cortex
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

ESCUDEIRO, S.S.; SOARES, P.M.; ALMEIDA, A.B.; LOBATO, R.F.G.; de ARAUJO, D.P.; MACEDO, D.S.; SOUSA, F.C.F.; PATROCÍNIO, M.C.A.; VASCONCELOS, S.M.M. Antidepressant Effect of Aminophylline After Ethanol Exposure. Sci. Pharm. 2013, 81, 211-222.

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