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Sci. Pharm. 2012, 80(3), 685-700; doi:10.3797/scipharm.1110-09

Anti-Inflammatory and Antinociceptive Activities of a Hydroethanolic Extract of Tamarindus indica Leaves

1
Department of Pharmacology, Adina Institute of Pharmaceutical Sciences, Sagar (M.P.) – 470002, India
2
Department of Pharmaceutical Sciences, Dr. H. S. Gaur University, Sagar (M.P.) – 470003, India
3
Department of Pharmacology, Shri Ram Institute of Technology, Jabalpur (M.P.) – 482002, India
*
Author to whom correspondence should be addressed.
Received: 11 October 2011 / Accepted: 1 April 2012 / Published: 1 April 2012
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Abstract

The present study aimed to investigate the anti-inflammatory and anti-nociceptive potential of a hydroethanolic extract of Tamarindus indica L. leaves (HTI) along with its possible mode of action. The anti-inflammatory activity of HTI was estimated by carrageenan-induced hind paw oedema in male Wistar albino rats. Furthermore, HTI was assessed to determine its effects on membrane stabilization. The antinociceptive action was determined by acetic acid-induced writhing, tail-flick, and the hot plate model. Oral administration of HTI at the dose of 500, 750, and 1000 mg/kg body weight produced significant (P < 0.01) anti-inflammatory as well as antinociceptive actions in a dose-dependent manner. Among all tested doses, 1000 mg/kg, p. o. reduced carrageenan-induced rat paw oedema at 1, 2, 3, and 4 h. Moreover, the 1000 mg/kg dose exhibited maximum percentage inhibition of acetic acid-induced writhing (48.9%), whereas standard drug diclofenac (25 mg/kg, p. o.) showed maximum inhibition (50.9%) of writhing. In the hot plate model, HTI (1000 mg/kg, orally) increased mean basal reaction time after 120 min (7.12±0.05 sec). In the tail flick model, HTI increased the maximum percentage of latency (36.06%), whereas the standard drug pethidine (4 mg/kg, intraperitoneally) showed maximum percentage of latency (43.85%) after 60 min. The findings of the present study supported anti-inflammatory and antinociceptive claims of T. indica as were mentioned in Indian traditional and folklore practices.
Keywords: Tamarindus indica; Carrageenan; Prostaglandins; Membrane stabilization; Flavonoids Tamarindus indica; Carrageenan; Prostaglandins; Membrane stabilization; Flavonoids
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

BHADORIYA, S.S.; MISHRA, V.; RAUT, S.; GANESHPURKAR, A.; JAIN, S.K. Anti-Inflammatory and Antinociceptive Activities of a Hydroethanolic Extract of Tamarindus indica Leaves. Sci. Pharm. 2012, 80, 685-700.

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