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Sci. Pharm. 2012, 80(3), 669-684; doi:10.3797/scipharm.1112-18

Effects of Calendula Essential Oil-Based Cream on Biochemical Parameters of Skin of Albino Rats against Ultraviolet B Radiation

1
Central Facility of Instrumentation, School of Pharmaceutical Sciences, IFTM University, Lodipur-Rajput, Moradabad-244001, India
2
Institute of Pharmaceutical Sciences and Research Centre, Bhagwant University, Ajmer-305004, India
3
Defence Research Laboratory, DRDO, Tezpur, Assam, India
*
Author to whom correspondence should be addressed.
Received: 22 December 2011 / Accepted: 16 April 2012 / Published: 16 April 2012
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Abstract

Reactive oxygen species (ROS) generated from UV-B radiation have the capacity to cause oxidative decomposition which leads to the formation of toxic components as well as lipid peroxidation. Considering this fact, the present study was performed to evaluate the effect of a cream (O/W) containing the essential oil of Calendula officinalis on biochemical parameters of the skin of albino rats against UV-B radiation. The fingerprint analysis of Calendula essential oil was performed by HPLC with special reference to 1,8-cineole and α-pinene. The results indicated that the treatment with creams containing 4% and 5% of Calendula essential oil caused a significant decrease in the malonyldialdehyde level, whereas the levels of catalase, glutathione, superoxide dismutase, ascorbic acid, and the total protein level were significantly increased after 1 month of daily irradiation and treatment when compared to untreated control groups. The results suggest that the cutaneous application of the essential oil of Calendula prevents UV-B-induced alterations in the level of antioxidants in skin tissue.
Keywords: Lipid peroxidation; UV-B radiation; Biochemical parameters; Calendula essential oil Lipid peroxidation; UV-B radiation; Biochemical parameters; Calendula essential oil
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

MISHRA, A.K.; MISHRA, A.; VERMA, A.; CHATTOPADHYAY, P. Effects of Calendula Essential Oil-Based Cream on Biochemical Parameters of Skin of Albino Rats against Ultraviolet B Radiation. Sci. Pharm. 2012, 80, 669-684.

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