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Sci. Pharm. 2012, 80(2), 457-468; doi:10.3797/scipharm.1106-13

Relaxant Effect of Essential Oil of Artemisia herba-alba Asso. on Rodent Jejunum Contractions

1
Laboratoire de Physiologie et d’Ethnopharmacologie, Université Mohammed I, Faculté des Sciences, BP 717, 60000, Oujda, Morocco
2
Laboratoire de Chimie appliquée et Environnement, Université Mohammed I, Faculté des Sciences, BP 717, 60000, Oujda, Morocco
3
Laboratoire de Biochimie, Université Mohammed I, Faculté des Sciences, BP 717, 60000, Oujda, Morocco
4
Laboratoire de Chimie Organique, Macromoléculaire et Produits Naturels, Université Mohammed I, Faculté des Sciences, BP 717, 60000, Oujda, Morocco
*
Author to whom correspondence should be addressed.
Received: 19 June 2011 / Accepted: 12 January 2012 / Published: 12 January 2012
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Abstract

Artemisia herba-alba Asso. is a shrub commonly encountered in Morocco. It is used in traditional medicine for treating intestinal disorders. The essential oil extracted from the plant’s aerial parts reversibly relaxed the spontaneous tonus of the rabbit jejunum in a reversible concentration dependent manner with an IC50 value of 97.33 ± 2.59 ng/ml and reversed the tonic contraction of rat jejunum induced by 75 mM KCl and 10−6 M carbachol with IC50 values of 115.5 ± 3.05 and 119.4 ± 20.86 ng/ml, respectively. The pre-treatment of the latter isolated intestine with this essential oil produced a dose-dependent shift of the Ca++ and CCh dose-response curve to the right, with suppression of the maximal effect, similar to the non-competitive antagonist effect on muscarinic receptors and calcium channel, respectively.
Keywords: Artemisia herba-alba Asso.; Essential oil; Rodent jejunum; Smooth muscle Artemisia herba-alba Asso.; Essential oil; Rodent jejunum; Smooth muscle
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

AZIZ, M.; KARIM, A.; EL OUARIACHI, E.M.; BOUYANZER, A.; AMRANI, S.; MEKHFI, H.; ZIYYAT, A.; MELHAOUI, A.; BNOUHAM, M.; LEGSSYER, A. Relaxant Effect of Essential Oil of Artemisia herba-alba Asso. on Rodent Jejunum Contractions. Sci. Pharm. 2012, 80, 457-468.

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