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Sci. Pharm. 2011, 79(1), 197-212; doi:10.3797/scipharm.1004-18

Preparation of Mucoadhesive Oral Patches Containing Tetracycline Hydrochloride and Carvacrol for Treatment of Local Mouth Bacterial Infections and Candidiasis

1
Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan
2
Faculty of Pharmacy, Al-Zaytoonah Private University of Jordan, Amman, Jordan
*
Author to whom correspondence should be addressed.
Received: 23 April 2010 / Accepted: 13 December 2010 / Published: 14 December 2010
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Abstract

The specific aim of this work was to prepare mucoadhesive patches containing tetracycline hydrochloride and carvacrol in an attempt to develop a novel oral drug delivery system for the treatment of mouth infections. The bilayered patches were prepared using ethyl cellulose as a backing layer and carbopol 934 as a matrix mucoadhesive layer. Patches were prepared with different loading amounts of tetracycline hydrochloride and carvacrol. The antimicrobial activity was assessed for the prepared patches using the disc-diffusion method against the yeast Candida albicans and five bacterial strains, including Pseudomonas aeruginosa, Escherichia coli, Bacillus cereus, Staphylococcus aureus, and Bacillus bronchispti. In this work, we highlighted the possibility of occurrence of a synergistic action between carvacrol and tetracycline. The best formulation was selected based on microbiological tests, drug release, ex-vivo mucoadhesive performance, and swelling index. Physical characteristics of the selected formulations were determined. These included pH, patch thickness, weight uniformity, content uniformity, folding endurance, and patch stability.
Keywords: Ethyl cellulose; Carbopol 934; Mucoadhesion; Oral infections Ethyl cellulose; Carbopol 934; Mucoadhesion; Oral infections
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

OBAIDAT, R.M.; BADER, A.; AL-RAJAB, W.; ABU SHEIKHA, G.; OBAIDAT, A.A. Preparation of Mucoadhesive Oral Patches Containing Tetracycline Hydrochloride and Carvacrol for Treatment of Local Mouth Bacterial Infections and Candidiasis. Sci. Pharm. 2011, 79, 197-212.

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