Next Article in Journal
Scientia Pharmaceutica, Autorenhinweise 2011
Previous Article in Journal
Preparation of Mucoadhesive Oral Patches Containing Tetracycline Hydrochloride and Carvacrol for Treatment of Local Mouth Bacterial Infections and Candidiasis
Article Menu

Article Versions

Export Article

Open AccessArticle
Sci. Pharm. 2010, 78(1), 93-102; doi:10.3797/scipharm.0908-09

Release Kinetic Studies of Aspirin Microcapsules from Ethyl Cellulose, Cellulose Acetate Phthalate and their Mixtures by Emulsion Solvent Evaporation Method

1
Kanak Manjari Institute of Pharmaceutical Sciences, Chhend Colony, Rourkela, Orissa, India
2
Department of Pharmaceutics, ISF College of Pharmacy, Moga (Punjab), India
*
Author to whom correspondence should be addressed.
Received: 15 August 2009 / Accepted: 17 December 2009 / Published: 19 December 2009
Download PDF [242 KB, uploaded 26 September 2016]

Abstract

The present study was oriented towards microencapsulation of aspirin and the study of its release kinetics. The desired encapsulation was achieved by emulsion solvent evaporation method using ethyl cellulose (EC), cellulose acetate phthalate (CAP) and their mixture (1:1) of polymeric constituents. Characterization of the formulations was performed by size, shape, drug loading efficiency and in-vitro drug release analysis. The in-vitro release profiles from different polymeric microcapsules were applied on different kinetic models. The prepared microcapsules were found free flowing and almost spherical in shape with particle sizes ranging from 300–700μm, having a loading efficiency of 75– 85%. The best fit model with the highest correlation coefficient was observed in Higuchi model, indicating diffusion controlled principle. The n value obtained from Korsemeyer-Peppas model varied between 0.5–0.7, confirming that the mechanism of drug release was diffusion controlled. Comparative studies revealed that the release of aspirin from EC microcapsules was slower as compared to that of CAP and their binary mixture.
Keywords: Aspirin; Ethyl Cellulose; Cellulose Acetate Phthalate; Microcapsules; Release Kinetics Aspirin; Ethyl Cellulose; Cellulose Acetate Phthalate; Microcapsules; Release Kinetics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

DASH, V.; MISHRA, S.K.; SINGH, M.; GOYAL, A.K.; RATH, G. Release Kinetic Studies of Aspirin Microcapsules from Ethyl Cellulose, Cellulose Acetate Phthalate and their Mixtures by Emulsion Solvent Evaporation Method. Sci. Pharm. 2010, 78, 93-102.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top