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Sci. Pharm. 2010, 78(3), 556; doi:10.3797/scipharm.cespt.8.LDD02

Non-Invasive Oligonucleotide Delivery System Based on a Thiolated Polymer: Development and In Vitro Evaluation

1
Department of Pharmaceutics, Faculty of Pharmacy, Gadjah Mada University, Sekip Utara, 55281 Yogyakarta, Indonesia
2
Department of Pharmaceutical Technology, Institute of Pharmacy, Leopold-Franzens-University of Innsbruck, Innrain 52, 6020 Innsbruck, Austria
*
Author to whom correspondence should be addressed.
Received: 12 July 2010 / Accepted: 12 July 2010 / Published: 12 July 2010
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Abstract

It was the purpose of this study to develop an oral oligonucleotide delivery system based on thiolated polymer/ reduced glutathione (GSH) system providing protective effect towards nucleases, permeation enhancement and controlled drug release. [...]
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

MARTIEN, R.; HOYER, H.; PERERA, G.; BERNKOP-SCHNÜRCH, A. Non-Invasive Oligonucleotide Delivery System Based on a Thiolated Polymer: Development and In Vitro Evaluation. Sci. Pharm. 2010, 78, 556.

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