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Sci. Pharm. 2010, 78(3), 507-516; doi:10.3797/scipharm.0911-11

Tamoxifen Citrate Encapsulated Sustained Release Liposomes: Preparation and Evaluation of Physicochemical Properties

1
Department of Pharmaceutical Technology, Division of Pharmaceutics, Jadavpur University, Kolkata700032, India
2
Pharmaceutical Science Department, 1401 Albrecht Blvd, 123 Sudro Hall, North Dakota State University, Fargo, ND-58102, USA
*
Author to whom correspondence should be addressed.
Received: 22 November 2009 / Accepted: 12 July 2010 / Published: 12 July 2010
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Abstract

The present study was designed for the development of a stable sustained release liposomal drug delivery system for tamoxifen citrate (TC) using soya phosphatidylcholine (SPC), cholesterol (CH) and span 20 as main ingredients. Liposomes were prepared by formation of thin lipid film followed by hydration. The mean vesicle diameter was found to be 203.5 ± 19.5 nm with 21% of the liposomal population having average diameter below 76.72 ± 6.7 nm. There was a good vesicular distribution with the polydispersity index of 0.442 ± 0.03. The maximum loading of drug was determined to be 53.60% of the initial amount that is 34.58 μg of drug per mg of lipid. Amongst the different storage conditions, liposomes stored at 2–8°C were found to be most stable and only 4% of the drug was lost over the storage period of 5 weeks. In vitro release studies of liposomes showed that 50% of drug was released within 3 hours (h) whereas 95% drug was released in 30 h. This indicates the usefulness of the liposomal delivery system for sustaining the in vitro release of tamoxifen citrate.
Keywords: Tamoxifen citrate; Liposome; Soya phosphatidylcholine; Cholesterol Tamoxifen citrate; Liposome; Soya phosphatidylcholine; Cholesterol
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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LAYEK, B.; MUKHERJEE, B. Tamoxifen Citrate Encapsulated Sustained Release Liposomes: Preparation and Evaluation of Physicochemical Properties. Sci. Pharm. 2010, 78, 507-516.

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