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Sci. Pharm. 2010, 78(1), 13-20; doi:10.3797/scipharm.0910-16

Different Spontaneous Pulmonary Metastasis Inhibitions against Lewis Lung Carcinoma in Mice by Bisdioxopiperazine Compounds of Different Treatment Schedules

1
Shanghai University, Shanghai 200444, PR China
2
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China
3
College of Sciences, Shanghai University, Shanghai 200444, PR China
*
Author to whom correspondence should be addressed.
Received: 25 October 2009 / Accepted: 28 December 2009 / Published: 29 December 2009
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Abstract

Spontaneous neoplasm metastasis, a fatalist pathological feature of cancer, is a long-evolving, multi-steps process that can now only be treated or controlled by drugs or immuno-modulators. As we have previously hypothesized, each drug or immuno-modulator might act differently within various stages of a metastasis. Therefore any researches helping to determine these differences will be beneficial for updating therapeutics for metastasis. In this work, we have testified this hypothesis by using a series of well-known anti-metastatic agents – Bisdioxopiperazine compounds.
Keywords: Neoplasm metastasis; Bisdioxopiperazine compounds; Cancer chemotherapy; Probimane; Razoxane Neoplasm metastasis; Bisdioxopiperazine compounds; Cancer chemotherapy; Probimane; Razoxane
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

LU, D.-Y.; WU, F.-G.; ZHEN, Z.-M.; LU, T.-R.; WU, H.-Y.; CHE, J.-Y.; XU, B. Different Spontaneous Pulmonary Metastasis Inhibitions against Lewis Lung Carcinoma in Mice by Bisdioxopiperazine Compounds of Different Treatment Schedules. Sci. Pharm. 2010, 78, 13-20.

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