Next Article in Journal
Different Spontaneous Pulmonary Metastasis Inhibitions against Lewis Lung Carcinoma in Mice by Bisdioxopiperazine Compounds of Different Treatment Schedules
Previous Article in Journal
New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities
Article Menu

Export Article

Open AccessArticle
Sci. Pharm. 2010, 78(1), 1-12; doi:10.3797/scipharm.0910-11

Studies on the Reactivity of (9-Methyl-5,6-dihydronaphtho[1',2':4,5]- thieno[2,3-d]pyrimidin-11-yl)hydrazine Towards Some Reagents for Biological Evaluation

1
Photochemistry Department, National Research Center, Elbehos Street, Dokki, Cairo, Egypt
2
Department of Natural and Microbial Products, National Research Center, Elbehos Street, Dokki, Cairo, Egypt
*
Author to whom correspondence should be addressed.
Received: 20 October 2009 / Accepted: 27 November 2009 / Published: 11 December 2009
Download PDF [205 KB, uploaded 26 September 2016]

Abstract

(9-Methyl-5,6-dihydronaphtho[1',2':4,5]thieno[2,3-d]pyrimidin-11-yl)hydrazine (1) was used as a precursor for preparation of some novel 1-(9-methyl-5,6- dihydronaphtho[1',2':4,5]thieno[2,3-d]pyrimidin-11-yl)-1H-pyrazoles 27, -1H-isoindole- 1,3(2H)-dione 8, and -pyridazin-3(2H)-one 9. Moreover, the acyclic C-nucleosides 10 and 11 were prepared by treating compound 1 with D-glucose. The in vitro antimicrobial activity of the tested compounds was evaluated by measuring the zone diameters and some of the prepared products showed potent antimicrobial activity in compared with those of well known drugs (standard). In general, the non-acetylated sugar hydrazone derivative 10 showed the highest antibacterial and antifungal potency among the tested compounds and standard with IZ = 22, 21 and 22 mm and MIC = 62.5 and 31.25 μg/ml, respectively.
Keywords: Thieno[2,3-d]pyrimidine; Pyrazole; Pyridazine; C-Nucleosides; Antimicrobial activity Thieno[2,3-d]pyrimidine; Pyrazole; Pyridazine; C-Nucleosides; Antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

RASHAD, A.E.; SHAMROUKH, A.H.; ABDEL-MEGEID, R.E.; SAYED, H.H.; ABDEL-WAHED, N.M. Studies on the Reactivity of (9-Methyl-5,6-dihydronaphtho[1',2':4,5]- thieno[2,3-d]pyrimidin-11-yl)hydrazine Towards Some Reagents for Biological Evaluation. Sci. Pharm. 2010, 78, 1-12.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top