Screening for Discovery of Novel Peroxisome Proliferator-Activated Receptor-alpha and -gamma Agonists and Nuclear Factor-κB Inhibitors by Luciferase Reporter Gene Assays

FAKHRUDIN, N.; VOGL, S.; PICKER, P.; HEISS, E. H.; SAUKEL, J.; REZNICEK, G.; KOPP, B.; ATANASOV, A. G.; DIRSCH, V. M.

doi:10.3797/scipharm.oephg.21.PO-41

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Abstract

16 April 2009

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Screening for Discovery of Novel Peroxisome Proliferator-Activated Receptor-alpha and -gamma Agonists and Nuclear Factor-κB Inhibitors by Luciferase Reporter Gene Assays

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Department of Pharmacognosy, University of Vienna, Althanstraße 14, 1090, Vienna, Austria

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Sci. Pharm.2009, 77(7), 240;https://doi.org/10.3797/scipharm.oephg.21.PO-41

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Peroxisome proliferator-activated receptors (PPARs) are transcription factors that belong to the nuclear receptor super family and represent promising therapeutic targets for several inflammatory and metabolic disorders. Nuclear factor-κB (NF-κB) is also a well-known transcription factor that regulates genes involved in inflammation.[...]

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