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Sci. Pharm. 2009, 77(Posters (PO)), 237; doi:10.3797/scipharm.oephg.21.PO-38 (registering DOI)

Gene Regulatory Effects of Sappan lignum Extract in a Cell Model of Joint Inflammation

1
Department of Pharmacology and Toxicology, University of Vienna, Althanstraße 14, 1090 Vienna, Austria
2
Department of Pharmaceutical Technoloy and Biopharmaceutics, University of Vienna, Althanstraße 14, 1090 Vienna, Austria
3
Faculty of Pharmacy, Chiang Mai University, Suthep Road, Muang, Chiang Mai 50200, Thailand
4
Medical University Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria
*
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
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Abstract

In recent years, intraarticular inflammation has been recognized to contribute to the symptoms and progression of osteoarthritis (OA). Inflammation in OA is associated with increased levels of catabolic enzymes and inflammatory mediators such as nitric oxide (NO), interleukin-1ß (IL-1ß) and tumor necrosis factor-α (TNF-α). Chondrocytes and infiltrating inflammatory cells, neurtrophils and macrophages, participate in the production of these catabolic mediators [1]. Extract from the heartwood of Caesalpinia sappan and its active components were reported to have antioxidative, antibacterial and anti-inflammatory effects [2]. The present study was designed to investigate whether ethanolic extract of C. sappan possesses anti-inflammatory activities in an in vitro model of joint inflammation comprising primary human osteoarthritic chondrocytes and differentiated THP-1 macrophage cells.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

WU, S.Q.; PHRUTIVORAPONGKUL, A.; CHIRARI, C.; UNGER, F.M.; GABOR, F.; VIERSTEIN, H.; TÖGEL, S. Gene Regulatory Effects of Sappan lignum Extract in a Cell Model of Joint Inflammation. Sci. Pharm. 2009, 77, 237.

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