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Sci. Pharm. 2009, 77(Posters (PO)), 236; doi:10.3797/scipharm.oephg.21.PO-37 (registering DOI)

Microspheres Containing Carnosic Acid for the Treatment of Basil Fungal Diseases

1
Dipartimento di Chimica e Tecnologie Farmaceutiche e Alimentari, Università di Genova, Via Brigata Salerno 13, 16147 Genova, Italy
2
Centro Regionale di Sperimentazione e Assistenza Agricola, Camera di Commercio I.A.A. di Savona, Regione Rollo, 98, 17031 Albenga, Italy
*
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
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Abstract

Microspheres loaded with carnosic acid (CA) as an active ingredient which was extracted from various species of Salvia L., were prepared by a spray drying technology. The matrix of the microspheres consisted of 85% deacetylated chitosan (average MW 55000 kDa), poloxamer P407 and carnosic acid. Briefly, chitosan and poloxamer P407 were dissolved in 1% v/v acetic acid followed by dispersion of carnosic acid under vigorous stirring. The dispersion was then fed into a spray dryer (190 Mini, Büchi, Flawil, Switzerland) and processed under the following operative conditions: T inlet 180°C, T outlet 120°C, air aspiration 70% and peristaltic pump 15% (feeding rate 4 mL/min). This process yielded microspheres with 5-8 μm in diameter containing 17% active ingredients corresponding to an encapsulation efficiency of 45% and a practical yield of 34%.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

RUSSO, E.; BISIO, A.; ROMUSSI, G.; PARODI, B.; CAVIGLIOLI, G.; MINUTO, G.; CAFAGGI, S. Microspheres Containing Carnosic Acid for the Treatment of Basil Fungal Diseases. Sci. Pharm. 2009, 77, 236.

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