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Sci. Pharm. 2009, 77(Posters (PO)), 209; https://doi.org/10.3797/scipharm.oephg.21.PO-10 (registering DOI)
Kolbe Electrolysis as a Novel Way of Generating Non-Proteinogenic Amino Acids
Department of Medicinal Chemistry, University of Vienna, Althanstraße 14, 1090, Vienna, Austria
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
Abstract By using Kolbe electrolysis , an anodic oxidation, carboxylic acids are able to form dimers through precent decarboxylation and generation of radicals. The scope of the Kolbe reaction can be considerably enhanced by cross-reaction of two different carboxylic acids. L-glutamic acid (Glu), which is blocked at the α-carboxyl and the amino group by protective groups, opens a new way for the synthesis of non-proteinogenic amino acids with defined stereochemistry. As examples Z-L-norleucine and amino acids containing a second amino group at its side chain were synthesized.
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DÖRNER, B.; KRATZEL, M. Kolbe Electrolysis as a Novel Way of Generating Non-Proteinogenic Amino Acids. Sci. Pharm. 2009, 77, 209.
DÖRNER B, KRATZEL M. Kolbe Electrolysis as a Novel Way of Generating Non-Proteinogenic Amino Acids. Scientia Pharmaceutica. 2009; 77(Posters (PO)):209.
DÖRNER, B.; KRATZEL, M. 2009. "Kolbe Electrolysis as a Novel Way of Generating Non-Proteinogenic Amino Acids." Sci. Pharm. 77, Posters (PO): 209.
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