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Sci. Pharm. 2009, 77(Posters (PO)), 202; doi:10.3797/scipharm.oephg.21.PO-03 (registering DOI)

Ligand Based Screening Tools for Insulin Receptor Activating Compounds

1
Department of Medicinal Chemistry, University of Vienna, Althanstraße 14, 1090, Vienna, Austria
2
Department of Pharmacognosy, University of Vienna, Althanstraße 14, 1090, Vienna, Austria
*
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
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Abstract

Current treatments of type 2 diabetes mellitus have sometimes severe side effects. Therefore, the identification of new treatments is still an urgent need. The binding of insulin to the extracellular part of the insulin receptor is a key step in the insulin signalling pathway. As type 2 diabetes is characterized among others by a resistance of cells against insulin, activating the insulin receptor might be an interesting approach. In 1999, Zhang et al. discovered a small molecule from a fungal extract which activates the human insulin receptor by binding directly to its intracellular domain [1]. This compound (L-783,281 or demethylasterriquinone B-1, DMAQ-B1) was shown to lower blood glucose levels in mouse models of type 2 diabetes mellitus.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

DIGLES, D.; DIRSCH, V.M.; ECKER, G.F. Ligand Based Screening Tools for Insulin Receptor Activating Compounds. Sci. Pharm. 2009, 77, 202.

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